Tobias Klein

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In this paper we present a novel ASR system combination technique able to combine systems producing word graphs of different structure and with different segmentations. The new method is based on the definition of a time frame-wise word error cost function in a minimum Bayes risk framework. In contrast to confusion network combination (CNC), it preserves(More)
Any opinions expressed here are those of the author(s) and not those of IZA. Research published in this series may include views on policy, but the institute itself takes no institutional policy positions. The Institute for the Study of Labor (IZA) in Bonn is a local and virtual international research center and a place of communication between science,(More)
Growth on glycerol has already been a topic of research for several yeast species, and recent publications deal with the regulatory mechanisms of glycerol assimilation by the fission yeast Schizosaccharomyces pombe. We investigated glycerol metabolism of S. pombe from a physiological point of view, characterizing growth and metabolism on a mixture of(More)
BACKGROUND In the future, oil- and gas-derived polymers may be replaced with bio-based polymers, produced from renewable feedstocks using engineered cell factories. Acrylic acid and acrylic esters with an estimated world annual production of approximately 6 million tons by 2017 can be derived from 3-hydroxypropionic acid (3HP), which can be produced by(More)
This study assesses matching estimators with fixed effects that first removes space and time effects before proceeding to apply standard matching based on participant characteristics. I use data from a novel profiling unemployment insurance program that allows the identification of both experimental and nonexperimental samples within the same local offices(More)
Metabolic bottlenecks play an increasing role in yeasts and mammalian cells applied for high-performance production of proteins, particularly of pharmaceutical ones that require complex posttranslational modifications. We review the present status and developments focusing on the rational metabolic engineering of such cells to optimize the supply chain for(More)
BACKGROUND The present study was carried out to assess quality of life, level of depression and perceived social support of patients on the waiting list and after a lung transplantation. METHODS 19 patients on the waiting list for lung transplantation and 20 patients 5 - 47 months after transplantation were enrolled in the study. Quality of life was(More)