Tobias Hirsch

Lars Steinstraesser10
Frank Jacobsen9
Hans-Ulrich Steinau8
Marcus Lehnhardt7
Adrien Daigeler6
10Lars Steinstraesser
9Frank Jacobsen
8Hans-Ulrich Steinau
7Marcus Lehnhardt
6Adrien Daigeler
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Playing musical instruments such as chordophones, percussions and keyboard types accompany with harmonic interaction of player's hand with the instruments. In this work, we present a novel approach that enables the user to imitate the music playing gestures around mobile devices. In our approach, touch-less gestures, which change magnetic field around the(More)
Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses. Both antimicrobial and/or immunomodulatory activities are an integral part of the process of innate immunity, which itself has many of the hallmarks of successful anti-infective(More)
Innate defense regulators (IDRs) are synthetic immunomodulatory versions of natural host defense peptides (HDP). IDRs mediate protection against bacterial challenge in the absence of direct antimicrobial activity, representing a novel approach to anti-infective and anti-inflammatory therapy. Previously, we reported that IDR-1018 selectively induced(More)
  • Lars Steinstraesser, Andrea Rittig, Kai Gevers, Michael Sorkin, Tobias Hirsch, Marco Kesting +5 others
  • 2009
OBJECTIVE Novel approaches to bridge the gap between clinical studies and experimental basic research of skin physiology are urgently needed. The aim of this study was to develop an effective surrogate model in which ex vivo full-thickness organ culture experiments may be performed. METHODS Human full skin from patients was placed into a stainless steel(More)
  • Tobias Hirsch, Malte Spielmann, Baraa Zuhaili, Till Koehler, Magdalena Fossum, Hans-Ulrich Steinau +4 others
  • 2008
BACKGROUND Wound infection is a common complication in diabetic patients. The progressive spread of infections and development of drug-resistant strains underline the need for further insights into bacterial behavior in the host in order to develop new therapeutic strategies. The aim of our study was to develop a large animal model suitable for monitoring(More)
Although bone regeneration is typically a reliable process, type 2 diabetes is associated with impaired or delayed healing processes. In addition, angiogenesis, a crucial step in bone regeneration, is often altered in the diabetic state. In this study, different stages of bone regeneration were characterized in an unicortical bone defect model comparing(More)
Methods for human skin gene therapy requires efficient and stable introduction of genes into skin cells. Transient cutaneous gene therapy is an attractive approach in the treatment of skin diseases. The 'Achilles heel' of adenoviral gene therapy is its immunogenicity and many aspects of adenovirus induced cutaneous immune reaction still remain unanswered,(More)
BACKGROUND Transfection efficacy after nonviral gene transfer in primary epithelial cells is limited. The aim of this study was to compare transfection efficacy of the recently available method of nucleofection with the established transfection reagent FuGENE6. METHODS Primary human keratinocytes (HKC), primary human fibroblasts (HFB), and a human(More)