Tobias Grundei

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E-Cadherin alterations have been reported frequently in sporadic diffuse type gastric and lobular breast carcinomas. Germline mutations of this gene have been identified recently in several gastric cancer families. We analyzed seven patients with a family history of the disease who had diffuse type gastric cancer diagnosed before the age of 45 for germline(More)
Gaze-evoked nystagmus occurs with cerebellar and brain-stem lesions and reflects a deficiency of the so-called common neural integrator. Experimental data show that loss of the neural integrator also abolishes slow conjugate eye movements, i.e. smooth pursuit eye movements and the vestibulo-ocular reflex (VOR). Since the smooth pursuit system has its own(More)
We analyzed a group of gastric carcinomas treated with a cisplatin-based neoadjuvant chemotherapy regimen for microsatellite instability (MSI) and loss of heterozygosity (LOH) to determine whether there is any relation between microsatellite alterations and therapy response. Pretherapeutic endoscopic biopsies of 37 patients were studied at 11 microsatellite(More)
Die Faktoren, die das Überleben der Patienten nach notfallmäßiger sowie elektiver Operation des AAA signifikant beeinflussen, sind in ihrer Wertigkeit Gegenstand der Diskussion. Anhand einer multivariaten Analyse erfolgte eine Untersuchung von Prognosefaktoren bei 528 Patienten mit rupturiertem und nichtrupturiertem AAA, die während eines(More)
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