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We have reviewed our laboratory's efforts to establish continuous human renal cancer cell lines. During the 16-year period of 1972 through 1987, 498 successive attempts resulted in establishment of 63 renal cancer cell lines. Of these lines, 46 were derived from primary kidney tumors and 17 from metastatic sites (lung, brain, bone, and lymph node).(More)
Any data based method is vulnerable to the problem of extrapolation, nonetheless there exists no unified theory on handling it. The main topic of this publication is to point out the differences in definitions of extrapolation and related methods. There are many different interpretations of extrapolation and a multitude of methods and algorithms, which(More)
This paper introduces the Extended Deterministic Local Search (EDLS) algorithm for Latin Hypercube (LH) designs. The main goal of the algorithm is to improve an existing algorithm towards a better uniformity of the data distribution, while maintaining a good computational performance. After presenting background information about LH designs and how to(More)
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