Tobias Cantz

Sort by:

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

Eva Warlich, Johannes Kuehle, +10 authors Axel Schambach
Molecular therapy : the journal of the American…
2011

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of reprogramming transcription factors. Expression levels of these factors strongly influence the overall… (More)

Stem cells in liver regeneration and therapy

Tobias Cantz, Michael P. Manns, Michael H. Ott
Cell and Tissue Research
2007

The liver has adapted to the inflow of ingested toxins by the evolutionary development of unique regenerative properties and responds to injury or tissue loss by the rapid division of mature cells.… (More)

Murine Embryonic Stem Cell-Derived Hepatic Progenitor Cells Engraft in Recipient Livers with Limited Capacity of Liver Tissue Formation.

Amar Deep Sharma, Tobias Cantz, +7 authors Michael Ott
Cell transplantation
2008

Directed endodermal differentiation of murine embryonic stem (ES) cells gives rise to a subset of cells with a hepatic phenotype. Such ES cell-derived hepatic progenitor cells (ES-HPC) can acquire… (More)

Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells.

Nils Pfaff, Nico Lachmann, +10 authors Thomas Moritz
Stem cells and development
2012

Heterogeneity among induced pluripotent stem cell (iPSC) lines with regard to their gene expression profile and differentiation potential has been described and at least partly linked to the tissue… (More)

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.

Nils Pfaff, Jan Fiedler, +4 authors Thomas Thum
EMBO reports
2011

Induced pluripotent stem cells (iPSCs) can be generated by overexpression of Oct4, Sox2 and Klf4 in murine fibroblasts. By conducting a microRNA (miRNA) library screen, we identified a set of miRNAs… (More)

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.

Nils Pfaff, Nico Lachmann, +9 authors Thomas Moritz
Stem cells
2013

Methylation-induced gene silencing represents a major obstacle to efficient transgene expression in pluripotent cells and thereof derived tissues. As ubiquitous chromatin opening elements (UCOE) have… (More)

Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy.

Mania Ackermann, Nico Lachmann, +11 authors Thomas Moritz
Biomaterials
2014

Epigenetic silencing of retroviral transgene expression in pluripotent stem cells (PSC) and their differentiated progeny constitutes a major roadblock for PSC-based gene therapy. As ubiquitous… (More)

Absence of OCT4 expression in somatic tumor cell lines.

Tobias Cantz, Göran Key, +4 authors Hans R. Schöler
Stem cells
2008

The POU-domain transcription factor OCT4 is associated with the pluripotent state of cells comprising the inner cell mass of pre-implantation embryos and has been known to play a critical role in the… (More)

Protein transduction from retroviral Gag precursors.

Christine Voelkel, Melanie Galla, +7 authors Christopher Baum
Proceedings of the National Academy of Sciences…
2010

Retroviral particles assemble a few thousand units of the Gag polyproteins. Proteolytic cleavage mediated by the retroviral protease forms the bioactive retroviral protein subunits before cell entry.… (More)

Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?

Pau Sancho-Bru, Mustapha Najimi, +9 authors Maurizio Muraca
Gut
2009

There has been recent progress in the isolation and characterisation of stem/progenitor cells that may differentiate towards the hepatic lineage. This has raised expectations that therapy of genetic… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences