Tobias A Alther

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Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from attraction to repulsion in order to move on with the next stage of their journey. The mechanisms underlying the change in axonal responsiveness are(More)
Axon guidance at choice points depends on the precise regulation of guidance receptors on the growth cone surface. Upon arrival at the intermediate target or choice point, a switch from attraction to repulsion is required for the axon to move on. Dorsal commissural (dI1) axons crossing the ventral midline of the spinal cord in the floor plate represent a(More)
  • Citation Philipp, Vera Melanie, Marc Niederkofler, Tobias Debrunner, Beat Alther, Esther T Kunz +8 others
  • 2012
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Background: Axons navigate to their future synaptic targets with the help of choice points, intermediate targets that express axon guidance cues. Once they reach a choice point, axons need to switch their response from(More)
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