Tiziana Ottone

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BACKGROUND Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after(More)
Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17) translocation is a well-recognized complication of cancer treatment with agents targeting topoisomerase II. However, cases are emerging after mitoxantrone therapy for multiple sclerosis (MS). Analysis of 12 cases of mitoxantrone-related t-APL in MS patients revealed an altered distribution(More)
MicroRNAs are key regulators of many biological processes, including cell differentiation. These small RNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Here, by using myeloid cell lines and primary(More)
Since the publication of this article, the authors have identified an error within Table 2, namely that the AML subgroups listed at the bottom of the table were incorrect. The correct table is shown here. The article has also been rectified, and now carries the correct information. The Publishers apologize for any inconvenience this has caused. a TCGA b(More)
The analyses carried out using 2 different bioinformatics pipelines (SomaticSniper and MuTect) on the same set of genomic data from 133 acute myeloid leukemia (AML) patients, sequenced inside the Cancer Genome Atlas project, gave discrepant results. We subsequently tested these 2 variant-calling pipelines on 20 leukemia samples from our series (19 primary(More)
our series, none of the 7 cases with NPM1 deletions showed at karyotypic examination a deletion that included the NPM1 gene locus at 5q35. However, it should be noted that the inaccuracy of the deleted region assignment by chromosome banding has been reported for 5q deletions in both MDS and AML. 11 Our findings suggest that NPM1 haploinsufficiency may have(More)
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