Tivadar Farkas

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Structural multiplicity has a significant effect on the solution of an MINLP model for process synthesis problems. The optimization model may also have built-in redundancy that cannot always be directly derived from the multiplicity of the superstructure. A basic GDP representation (BGR) involving logical relations is defined, and can be constructed by(More)
The essential problems, namely representativeness and uniqueness, in defining mixed integer non-linear programming (MINLP) representation (MR) is solved in Part I by first defining a basic MR (BMR) that: (1) can be automatically constructed from an easier formable standard GDP representation and (2) serves as a reference representation. Binary and(More)
  • Abdulfatah M Emhamed, Zoltan Lelkes, Endre Rev, Tivadar Farkas, Zsolt Fonyo, Duncan M Fraser
  • 2005
A new hybrid optimisation method is presented, that is fairly robust and can be accomplished in an automatic way. The main idea is using integer cuts and bounds, calculated based on driving force plot analysis, for the lean streams to decrease the possibility of being trapped in local optimum. A new initial solution is constructed only if the MINLP solution(More)
There is considerable interest in developing dopamine transporter (DAT) inhibitors as potential therapies for the treatment of cocaine abuse. We report herein our pharmacophore-based discovery and molecular modeling-assisted rational design of 2,3-disubstituted quinuclidines as potent DAT inhibitors with a novel chemical scaffold. Through 3-D-database(More)
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