Tino Schulz

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We previously identified Legionella pneumophila PlaB as the major cell-associated phospholipase A/lysophospholipase A with contact-dependent hemolytic activity. In this study, we further characterized this protein and found it to be involved in the virulence of L. pneumophila. PlaB was mainly expressed and active during exponential growth. Active PlaB was(More)
In Legionella pneumophila, the regulation of the flagellum and the expression of virulence traits are linked. FleQ, RpoN and FliA are the major regulators of the flagellar regulon. We demonstrated here that all three regulatory proteins mentioned (FleQ, RpoN and FliA) are necessary for full in vivo fitness of L. pneumophila strains Corby and Paris. In this(More)
Francisella isolates from patients suffering from tularemia in Germany are generally strains of the species F. tularensis subsp. holarctica. To our knowledge, no other Francisella species are known for Germany. Recently, a new Francisella species could be isolated from a water reservoir of a cooling tower in Germany. We identified a Francisella sp. (isolate(More)
Legionella oakridgensis is able to cause Legionnaires' disease, but is less virulent compared to L. pneumophila strains and very rarely associated with human disease. L. oakridgensis is the only species of the family legionellae which is able to grow on media without additional cysteine. In contrast to earlier publications, we found that L. oakridgensis is(More)
Given a rational family of planar rational curves in a certain region of interest, we are interested in computing an implicit representation of the envelope. The points of the envelope correspond to the zero set of a function (which represents the envelope condition) in the parameter space combining the curve parameter and the motion parameter. We analyze(More)
We present a new method for constructing G blending surfaces between an arbitrary number of canal surfaces. The topological relation of the canal surfaces is specified via a convex polyhedron and the design technique is based on a generalization of the medial surface transform. The resulting blend surface consists of trimmed envelopes of oneand(More)
Ringed surfaces and canal surfaces are surfaces that contain a one-parameter family of circles. Ringed surfaces can be described by a radius function, a directrix curve and vector field along the directrix curve, which specifies the normals of the planes that contain the circles. In particular, the class of ringed surfaces includes canal surfaces, which can(More)
Legionella oakridgensis causes Legionnaires' disease but is known to be less virulent than Legionella pneumophilaL. oakridgensis is one of the Legionella species that is nonflagellated. The genes of the flagellar regulon are absent, except those encoding the alternative sigma-28 factor (FliA) and its anti-sigma-28 factor (FlgM). Similar to L. oakridgensis,(More)
The envelope of a family of real, rational hypersurfaces is defined by an implicit equation in the parameter space. This equation can be decomposed into factors that are mapped to varieties of different dimension. The factorization can be found using solely gcd computations and polynomial divisions. The decomposition is used to derive some general results(More)