Tingyu Liu

Gal Bitan4
Aida Attar3
4Gal Bitan
3Aida Attar
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Alzheimer's disease is a devastating cureless neurodegenerative disorder affecting >35 million people worldwide. The disease is caused by toxic oligomers and aggregates of amyloid β protein and the microtubule-associated protein tau. Recently, the Lys-specific molecular tweezer CLR01 has been shown to inhibit aggregation and toxicity of multiple(More)
Currently, workflow technology is widely used to facilitate the working process in enterprise information systems (EIS), and it has the potential to reduce design time, enhance product quality and decrease product cost. However, significant limitations still exist: as an important task in the context of workflow, many present resource allocation operations(More)
Abnormal protein assembly causes multiple devastating disorders in the central nervous system (CNS), such as Alzheimer's, Parkinson's, Huntington's, and prion diseases. Due to the now extended human lifespan, these diseases have been increasing in prevalence, resulting in major public health problems and the associated financial difficulties worldwide. The(More)
  • Jackob Moskovitz, Panchanan Maiti, Dahabada H J Lopes, Derek B Oien, Aida Attar, Tingyu Liu +3 others
  • 2011
Self-assembly of amyloid β-protein (Aβ) into toxic oligomers and fibrillar polymers is believed to cause Alzheimer's disease (AD). In the AD brain, a high percentage of Aβ contains Met-sulfoxide at position 35, though the role this modification plays in AD is not clear. Oxidation of Met(35) to sulfoxide has been reported to decrease the extent of Aβ(More)
Alzheimer's disease is a progressive neurodegenerative disease that manifests as memory loss, cognitive dysfunction, and dementia. Animal models of Alzheimer's disease have been instrumental in understanding the underlying pathological mechanism and in evaluation of potential therapies. The triple transgenic (3 × Tg) mouse model of AD is unique because it(More)
The variety of product types and spesifications make new product development (NPD) tasks tough work in discrete manufacturing enterprises, which makes it a common strategy to refer to similar outcomes (e.g. the product drawings, work instructions, etc.) of former tasks during NPD processes. To improve the efficiency of discovering similar historical(More)
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