Tingting Tan

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Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesis, we report that B cells and humoral immunity foster cancer(More)
The family of antimicrobial peptide, cathelicidins, which plays important roles against infections in animals, has been identified from many species. Here, we identified a novel avian cathelicidin ortholog from ducks and named dCATH. The cDNA sequence of dCATH encodes a predicted 146-amino-acid polypeptide composed of a 17-residue signal peptide, a(More)
Antimicrobial peptides have attracted considerable attention because of their broad-spectrum antimicrobial activity and their low prognostic to induce antibiotic resistance which is the most common source of failure in bacterial infection treatment along with biofilms. The method to design hybrid peptide integrating different functional domains of peptides(More)
1Department of Pathology University of California, San Francisco, San Francisco, CA 94143, USA 2Helen Diller Family Comprehensive Cancer Center University of California, San Francisco, San Francisco, CA 94143, USA 3Angiogenesis and Tumor Targeting Research Unit, San Raffaele-Telethon Institute for Gene Therapy and Vita-Salute San Raffaele University, San(More)
Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanced pro-tumor humoral and/or innate(More)
  • Tingting Tan
  • 2010 International Conference of Information…
  • 2010
This document has proposed an innovation business model, to use crowdsourcing to assist blogs website capturing value. With the concept of crowdsourcing, the paper focuses on innovative business model in three basic functions: market segmentation, value proposition and strategic positioning. This paper reveals the blog content produced by consumer groups,(More)
Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural antimicrobial peptides. FV7 (FRIRVRV-NH₂), a consensus amphiphilic sequence was identified as being analogous to host defense peptides. In this study, we(More)
To generate effective antimicrobial peptides (AMPs) with good antimicrobial activities and cell selectivity, many synthetic strategies have been implemented to facilitate the development of AMPs. However, these synthetic strategies represent only a small proportion of the methods used for the development of AMPs and are not optimal with the requirements(More)
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