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a r t i c l e i n f o a b s t r a c t To estimate the future development of one technology and make decisions whether to invest in it or not, one needs to know the current stage of its technology life cycle (TLC). The dominant approach to analysing TLC uses the S-curve to observe patent applications over time. But using the patent application counts alone(More)
BACKGROUND Lysosome-associated protein transmembrane 4 beta (LAPTM4B) has two alleles named LAPTM4B*1 and LAPTM4B*2. Allele *1 contains only one copy of a 19-bp sequence at the 5'UTR in the first exon, whereas this sequence of allele*2 is duplicated and arrayed as a tandem repeat. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk(More)
Congenital and progressive hearing impairment is a common distressing disease. The progressive dominant hearing loss DFNA28 in human is associated with a frameshift mutation of Grainyhead-like 2 (GRHL2) but its etiology and mechanism remain unknown. Here we report a zebrafish grhl2b(T086) mutant line in which grhl2b expression is interrupted by an insertion(More)
The supply chain is a dynamic and integrated system in which all enterprises are integrated to obtain optimization of the whole chain. Integration is a process of redefining and connecting parts of a whole in order to form a new one. In traditional supply chain integration, the definitions of parts are usually limited by the boundary of the enterprises: the(More)
We explore pilot web-based methods to probe the strategies followed by new small and medium-sized technology-based firms as they seek to commercialize emerging technologies. Tracking and understanding the behavior of such early commercial entrants is not straightforward because smaller firms with limited resources do not always widely engage in readily(More)
BACKGROUND Acupuncture is widely used in China to treat functional dyspepsia (FD). However, its effectiveness in the treatment of FD, and whether FD-specific acupoints exist, are controversial. So this study aims to determine if acupuncture is an effective treatment for FD and if acupoint specificity exists according to traditional acupuncture meridians and(More)
OBJECTIVES Acupuncture is a commonly used therapy for treating functional dyspepsia (FD), although the mechanism remains unclear. The objectives of this study were to investigate the differences in cerebral glycometabolism changes evoked by acupuncture and sham acupuncture and to explore the possible correlations between brain responses and clinical(More)
BACKGROUND BCL-2 (B-cell leukemia/lymphoma 2) gene has been demonstrated to be associated with breast cancer development and a single nucleotide polymorphism (SNP; -938C > A) has been identified recently. To investigate whether this polymorphism functions as a modifier of breast cancer development, we analyzed the distribution of genotype frequency, as well(More)
BACKGROUND AND MOTIVATION The effectiveness of using acupuncture to treat migraine is rarely and even suspectedly reported in the literature. In this article, we report the design and the protocol of a randomized controlled large-scale trial to treat migraine using acupuncture, aiming at testifying it is effective to use acupuncture to treat migraine. We(More)