Tingan Chen

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BACKGROUND New tumor markers and markers of tumor progression are needed for improved staging and for better assessment of treatment of many cancers. Gene expression profiling techniques offer the opportunity to discover such markers. We investigated the feasibility of sample pooling strategy in combination with a novel analysis algorithm to identify(More)
We investigate a three-dimensional multiscale model of vascular tumour growth, which couples blood flow, angiogenesis, vascular remodelling, nutrient/growth factor transport, movement of, and interactions between, normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. In particular, we determine how the domain size, aspect(More)
The adenomatous polyposis coli (APC) gene, a member of the WNT pathway, has been shown to assign intestinal epithelial cells to a program of proliferation or differentiation through regulation of the beta-catenin/TCF-4 complex. Wild-type APC, in certain cellular contexts, appears to induce differentiation and apoptosis, although mutant forms of APC, known(More)
Despite the great progress that has been made in understanding cancer biology and the potential molecular targets for its treatment, the majority of drugs fail in the clinical trials. This may be attributed (at least in part) to the complexity of interstitial drug transport in the patient's body, which is hard to test experimentally. Similarly, recent(More)
Angiogenesis marks an important turning point in the growth of solid tumours. Avascular tumours rely on diffusive transport to supply them with the nutrients they need to grow and, as a result, they typically grow to a maximal size of several millimetres in diameter. Growth stops when the rate at which nutrient-starved cells in the tumour centre die(More)
A more detailed description of the mathematical model is presented in this appendix. Our description starts at the smallest spatial scale, namely the subcellular layer. Then the cellular and diffusible layers are introduced, and finally the vascular layer is introduced. Interactions between these layers are highlighted in the final part of this section(More)
The adenomatous polyposis coli (APC) gene, a member of the WNT pathway, has been shown to assign intestinal epithelial cells to a program of proliferation or differentiation through regulation of the ␤-catenin/ TCF-4 complex. Wild-type APC, in certain cellular contexts, appears to induce differentiation and apoptosis, although mutant forms of APC, known to(More)
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