Ting-wen Lei

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AIM To clarify the mechanisms of integrin overexpression in negatively regulating the cell cycle control of hepatocellular carcinoma cells SMMC-7721. METHODS The cell cycle pattern was determined by flow cytometry. The mRNA and protein expression levels were assayed by RT-PCR and Western blot, respectively. Stable transfection was performed by(More)
Over-expression of cleaved cyclin E in breast tumors is closely associated with tumor progression and resistance to antiestrogens. 17β-Estradiol (E2) has been recently shown to induce cyclin E processing in breast cancer cells. Tamoxifen has been used in patients with estrogen-sensitive breast cancer, yet resistance to antiestrogens and recurrence will(More)
OBJECTIVE To study effects of Rhaponticum uniflorum on the activities and mRNA expression of cytochrome P4503A1 in rats hepatocytes. METHODS Rat hepatocytes sandwich cultures were treated by Rhaponticum uniflorum in different concentrations (15.6, 31.2, 62.4 mg/ml) for 48 hours. The enzymic activities of CYP3A1 were reflected by the activities of liver(More)
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