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The effect of environmental temperature on neuronal spiking behaviours is investigated by numerically simulating the temperature dependence of spiking threshold of the Hodgkin-Huxley neuron subject to synaptic stimulus. We find that the spiking threshold exhibits a global minimum in a " comfortable temperature " range where spike initiation needs weakest(More)
BACKGROUND Previous reports have shown that the ERG gene is hypermethylated in the placenta and hypomethylated in maternal blood cells. In this study, we explore the feasibility of hypermethylated ERG as a cell-free fetal (cff) DNA biomarker for non-invasive prenatal testing (NIPT) of Down syndrome. METHODS We randomly selected 90 healthy pregnant women,(More)
Although the phenylalanine/tyrosine ratio in blood has been the gold standard for diagnosis of phenylketonuria (PKU), the disadvantages of invasive sample collection and false positive error limited the application of this discriminator in the diagnosis of PKU to some extent. The aim of this study was to develop a new standard with high sensitivity and(More)
Resource space model (RSM) is a semantic data model to manage and share heterogeneous resources by appropriately classifying the contents of resources in the future interconnection environment. The current storage model C-tree for RSM is too complicated to develop an available sharing tool which affects the study of RSM. For simplifying and improving the(More)
We have developed a linearization method to investigate the subthreshold oscillatory behaviors in nonlinear autonomous systems. By considering firstly the neuronal system as an example, we show that this theoretical approach can predict quantitatively the subthreshold oscillatory activities, including the damping coefficients and the oscillatory frequencies(More)
The resistance distance r G (u, v) between two vertices u, v of a connected graph G is defined as the effective resistance between them in the corresponding electrical network constructed from G by replacing each edge of G with a unit resistor. Let G be a connected graph, the degree resistance distance of G is defined as D R (G) = {u,v}⊆V (G) [d(u) +(More)