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BACKGROUND Seroprevalence data suggest that a third of the world's population has been infected with the hepatitis E virus. Our aim was to assess efficacy and safety of a recombinant hepatitis E vaccine, HEV 239 (Hecolin; Xiamen Innovax Biotech, Xiamen, China) in a randomised, double-blind, placebo-controlled, phase 3 trial. METHODS Healthy adults aged(More)
Patient’s privacy-preserving, security and mutual authentication between patient and the medical server are the important mechanism in connected health care applications, such as telecare medical information systems and personally controlled health records systems. In 2013, Wen showed that Das et al.’s scheme is vulnerable to the replay attack, user(More)
This paper describes a bidirectional, differential, 16 Gb/s per link memory interface that includes a Controller and an emulated DRAM physical interface (PHY) designed in 65 nm CMOS. To achieve high data rate, the interface employs the following technology ingredients: asymmetric equalization, asymmetric timing calibration, asymmetric link margining,(More)
This policy study evaluates the effects of the “Lifeline” and “Linkup” subsidy programs on telephone penetration rates of low-income households, and provides a framework for evaluating similar policies for Internet access. These two programs, respectively, subsidize the monthly subscription and initial connection prices for low-income households. Our demand(More)
The authors investigated whether polymorphisms in two maternal metabolic genes, cytochrome P-450 1A1 (CYP1A1) MspI and epoxide hydrolase 1 (EPHX1) Tyr113His, affect the association of maternal passive smoking with infant birth weight. The study was conducted in a cohort of 1,388 newly married mothers of liveborn singletons who worked in textile mills in(More)
Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain parenchyma along the paravascular pathway. However the direct evidence for roles of AQP4 in the pathophysiology of(More)
The first prophylactic vaccine, Hecolin®, against hepatitis E virus (HEV) infection and the HEV associated disease was approved by China's State Food and Drug Administration (SFDA) in December 2011. Key milestones during the 14-year HEV vaccine development are summarized in this commentary.  After years of innovative research the recombinant virus-like(More)
A technique for reducing the supply voltage sensitivity of a ring oscillator using on-chip calibration is described. A 1-V 0.13m CMOS PLL demonstrates robust performance against VCO supply noise over operating frequencies of 0.5 to 2 GHz. In the presence of a 10-mV 1-MHz VCO supply noise, the measured rms jitter of the proposed PLL with on-chip calibration(More)
BACKGROUND Hepatitis E is caused by two viral genotype groups: human types and zoonotic types. Current understanding of the epidemiology of the zoonotic hepatitis E disease is founded largely on hospital-based studies. METHODS The epidemiology of hepatitis E was investigated in a community-based surveillance study conducted over one year in a rural city(More)