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The regulatory map of a genome consists of the binding sites for proteins that determine the transcription of nearby genes. An initial regulatory map for S. cerevisiae was recently published using six motif discovery programs to analyze genome-wide chromatin immunoprecipitation data for 203 transcription factors. The programs were used to identify sequence(More)
New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (microbiota) is essential for processing dietary polysaccharides. We found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the(More)
The UCSC Genome Browser (https://genome.ucsc.edu) provides a web interface for exploring annotated genome assemblies. The assemblies and annotation tracks are updated on an ongoing basis-12 assemblies and more than 28 tracks were added in the past year. Two recent additions are a display of CRISPR/Cas9 guide sequences and an interactive navigator for gene(More)
This paper presents PrivacyGrid - a framework for supporting anonymous location-based queries in mobile information delivery systems. The PrivacyGrid framework offers three unique capabilities. First, it provides a location privacy protection preference profile model, called location P3P, which allows mobile users to explicitly define their preferred(More)
MOTIVATION Discovery of regulatory motifs in unaligned DNA sequences remains a fundamental problem in computational biology. Two categories of algorithms have been developed to identify common motifs from a set of DNA sequences. The first can be called a 'multiple genes, single species' approach. It proposes that a degenerate motif is embedded in some or(More)
Sparse representation-based classifier (SRC), a combined result of machine learning and compressed sensing, shows its good classification performance on face image data. However, SRC could not well classify the data with the same direction distribution. The same direction distribution means that the sample vectors belonging to different classes distribute(More)
In this tutorial overview, the principles, advantages, challenges, and practical requirements of optical orthogonal frequency division multiplexing (OFDM)-based optical access are presented, with an emphasis on orthogonal frequency division multiple access (OFDMA) for application in next-generation passive optical networks (PON). General OFDM principles,(More)
Although it is known that the methylation of DNA in 5' promoters suppresses gene expression, the role of DNA methylation in gene bodies is unclear. In mammals, tissue- and cell type-specific methylation is present in a small percentage of 5' CpG island (CGI) promoters, whereas a far greater proportion occurs across gene bodies, coinciding with highly(More)
Consider a mobile client who travels over roads and wishes to receive location-based services (LBS) from untrusted service providers. How might the user obtain such services without exposing her private position information? Meanwhile, how could the privacy protection mechanism incur no disincentive, e.g., excessive computation or communication cost, for(More)
Roadmap Epigenomics Consortium{, Anshul Kundaje*, Wouter Meuleman*, Jason Ernst*, Misha Bilenky*, Angela Yen, Alireza Heravi-Moussavi, Pouya Kheradpour, Zhizhuo Zhang, Jianrong Wang, Michael J. Ziller, Viren Amin, John W. Whitaker, Matthew D. Schultz, Lucas D. Ward, Abhishek Sarkar, Gerald Quon, Richard S. Sandstrom, Matthew L. Eaton, Yi-Chieh Wu, Andreas(More)