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Accessibility is a concept that is not entirely easy to define. Gould (1969) once stated that it is a 'slippery notion … one of those common terms that everyone uses until faced with the problem of defining and measuring it'. Considerable research over the last 40 years has been devoted to defining and measuring accessibility, ranging from access to jobs(More)
Landscape ecologists have increasingly turned to the use of landscape graphs in which a landscape is represented as a set of nodes (habitat patches) connected by links representing inter-patch-dispersal. This study explores the use of a graph-based regionalization method, Graph-based REgionalization with Clustering And Partitioning (GraphRECAP), to detect(More)
BACKGROUND Brain tumor patients often associated with losses of the small-world configuration and neurocognitive functions before operations. However, few studies were performed on the impairments of frontal lobe low-grade gliomas (LGG) after tumor resection using small-world network features. METHODOLOGY/PRINCIPAL FINDINGS To detect differences in the(More)
Nitric oxide (NO) reacts rapidly with superoxide anion and produces peroxynitrite (ONOO(-)), which is a highly reactive free radical that has been shown to mediate much of the toxicity of NO. ONOO(-) has also been implicated as playing a role in the pathology of various brain disorders. The aim of this study was to investigate the actions of ONOO(-) on(More)
Accumulating evidence indicates that the polyphenol resveratrol (trans-3, 5, 4"-trihydroxystibene, RVT) potently protects against cerebral ischemia neuronal damage due to its oxygen free radicals scavenging and antioxidant properties. However, it is unknown whether RVT can attenuate ischemia-induced early impairment of neuronal excitability. To address this(More)
The newly proposed glioma stem cell (GSC) hypothesis may re-model the way we diagnose and treat the tumor, which highlights the need for a complete knowledge on the genetic and epigenetic "blueprints" of GSCs. To identify the true "stemness" signatures, pure GSC populations are primarily needed. Reliable in vitro methods enriching for GSCs and thereby(More)
PURPOSE Brain iron deposition has been proposed to play an important role in the pathophysiology of neurodegenerative diseases. The aim of this study was to investigate the correlation of brain iron accumulation with the severity of cognitive impairment in patients with Alzheimer disease (AD). MATERIALS AND METHODS This study was approved by the(More)
c-Jun N-terminal kinase (JNK) is implicated in cell death in neurodegenerative disorders and has been taken as a critical point between the physiological and pathological status. JNK specific inhibitor SP600125 has been found to have a protective effect against transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 region. Former(More)
The mortality of patients with malignant gliomas remains high despite the advancement in multi-modal therapy including surgery, radio- and chemotherapy. Glioma stem cells (GSCs), sharing some characteristics with normal neural stem cells (NSCs), contribute to the cellular origin for primary gliomas and the recurrence of malignant gliomas after current(More)
Chip-scale, optical microcavity-based biosensors typically employ an ultra-high-quality microcavity and require a precision wavelength-tunable laser for exciting the cavity resonance. For point-of-care applications, however, such a system based on measurements in the spectral domain is prone to equipment noise and not portable. An alternative(More)