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An UPLC-MS/MS method was developed for the determination of serotonin (5-HT), dopamine (DA), their phase I metabolites 5-HIAA, DOPAC and HVA, and their sulfate and glucuronide conjugates in human brain microdialysis samples obtained from two patients with acute brain injuries, ventricular cerebrospinal fluid (CSF) samples obtained from four patients with(More)
Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from peripheral sources. In the current study, permeation of the blood-brain barrier (BBB) by DA-S was studied by injecting 13C6-labelled regioisomers of DA-S(More)
  • Niklas Laitinen, Jouko Yliruusi, Jyrki Docent, Heinämäki, Robert T Forbes, Yliopistopaino Helsinki +5 others
  • 2003
The physical characterisation of pharmaceutical solids is fundamental in the drug development process. At present, the utilisation of descriptive image information in pharmaceutical technology is very limited. Subsequently, the development of this discipline creates a challenge within the characterisation of pharmaceutical solids. Research contributions(More)
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