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Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency
Fenoterol is a widely used anti‐asthmatic and tocolytic agent, but high plasma concentrations of fenoterol may lead to severe and even fatal adverse reactions. We studied whether heritable deficiencyExpand
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Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?
To the editor: Recently, the Met408-Del420 haplotype in the OCT1 gene (the combination of methionine at codon 408 and a deletion of another methionine at codon 420) was associated with lack ofExpand
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Erratum to: Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families
Erratum to: Jiayin Chen, Jürgen Brockmöller, Tina Seitz, Jörg König, Mladen V. Tzvetkov and Xijing Chen. 2017. Tropane alkaloids as substrates and inhibitors of human organic cation transporters ofExpand
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Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine
Background Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cationExpand
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Heparins modulate the IFN-γ-induced production of chemokines in human breast cancer cells
Heparins seem to improve survival in patients with advanced malignancies independently of their anticoagulatory function. As the treatment options in advanced and metastatic breast cancer are stillExpand
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Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families
Abstract Tropane alkaloids and their derivatives are anticholinergic drugs with narrow therapeutic range. Here we characterize the organic cation transporters from the SLC22 (OCT1, OCT2, and OCT3)Expand
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Suppressor genes of V-RAF transformation: protein kinase C-ξ reverts cellular transformation by inducing prolonged expression of junB and EGR-1
Z 14 EXPRESSION OF PROTEIN KINASE C ISOENZYMES AND CORRELATION WITH TUMOR INVASIVENESS IN VITRO R. Engers, T. Heymer, D. Fabbro, S. Stabel, S. Mrzyk, C.D. Gerharz, H.E. Gabbert Objective: ProteinExpand