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Previous studies have found that treatment with lithium over a 4-week period may increase the concentration of N-acetyl-aspartate (NAA) in both bipolar patients and controls. In view of other findings indicating that NAA concentrations may be a good marker for neuronal viability and/or functioning, it has been further suggested that some of the long term… (More)
BACKGROUND It has been proposed that lithium may be clinically effective due to its actions on the phosphoinositol second messenger system (PI-cycle). Studies have also suggested that untreated manic patients may have raised myo-inositol and phosphomonoester (PME) concentrations and also that unmedicated euthymic bipolar patients may have lowered PME… (More)
BACKGROUND Lithium may affect brain choline concentrations, and this effect has been proposed to potentially explain its clinical efficacy. Since dextro-amphetamine is a useful human model of mania, we were interested in determining firstly whether dextro-amphetamine would alter brain choline concentrations, and secondly to determine if lithium would… (More)
Background: It has been suggested that lithium increases choline concentrations, although previous human studies examining this possibility using 1 H magnetic resonance spectroscopy (1 H MRS) have had mixed results: some found increases while most found no differences.
The assessment of myocardial viability in the left ventricle (LV) of patients with coronary artery disease is essential for determining prognosis and planning appropriate therapy. Typically, population-based models are used to associate regions containing non-viable (dead) myocardial tissue with a particular coronary artery. We propose a technique to… (More)
AIMS To help determine the effects of dextro-amphetamine on the phosphoinositol cycle (PI-cycle) in humans, (1)H and (31)P magnetic resonance spectroscopy (MRS) was utilized in 17 healthy volunteers. This was an open-label study carried out before and after administration of 20 mg oral dextro-amphetamine. Subjects also rated the subjective effects of… (More)
Several implant systems may be used to fuse the skull to the upper cervical spine (occipitocervical fusion). Current biomechanical evaluation is restricted by the limitations of human cadaveric specimens. This paper describes the design and validation of a synthetic testing model of the occipital bone. Data from thickness measurement and pull-out strength… (More)