Tina M. Thorne

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Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter

Eric Delpire, Jianming Lu, Roger England, C. W. Dull, Tina M. Thorne
Nature Genetics
1999

Deafness can result from a variety of gene defects. Some genes involved in the physiology of hearing encode membrane transporters that regulate the ionic composition of the fluid bathing the inner… (More)

Netrins promote developmental and therapeutic angiogenesis.

Brent Wilson, Masaaki Ii, +13 authors Dean Y. Li
Science
2006

Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of… (More)

Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.

Douglas W. Losordo, Richard A. Schatz, +29 authors Timothy D. Henry
Circulation
2007

BACKGROUND A growing population of patients with coronary artery disease experiences angina that is not amenable to revascularization and is refractory to medical therapy. Preclinical studies have… (More)

Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.

Gangjian Qin, Raj Kishore, +14 authors Douglas W. Losordo
Proceedings of the National Academy of Sciences…
2006

The transcription factor E2F1 is known to regulate cell proliferation and has been thought to modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in E2F1 exhibit… (More)

Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling

Kengo Kusano, Roberto Pola, +23 authors Douglas W. Losordo
Nature Medicine
2005

Sonic hedgehog (Shh) is a crucial regulator of organ development during embryogenesis. We investigated whether intramyocardial gene transfer of naked DNA encoding human Shh (phShh) could promote a… (More)

Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.

Kazuichi Maruyama, Jun Asai, Masaaki Ii, Tina M. Thorne, Douglas W. Losordo, Patricia A D'Amore
The American journal of pathology
2007

Impaired wound healing is a common complication of diabetes. Although it is well known that both macrophages and blood vessels are critical to wound repair, the role of wound-associated lymphatic… (More)

Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity.

Susmita Sahoo, Ekaterina Klychko, +11 authors Douglas W. Losordo
Circulation research
2011

RATIONALE Transplantation of human CD34(+) stem cells to ischemic tissues has been associated with reduced angina, improved exercise time, and reduced amputation rates in phase 2 clinical trials and… (More)

Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via…

Atsushi Iwakura, Shubha Shastry, +11 authors Douglas W. Losordo
Circulation
2006

BACKGROUND Recent data have indicated that estradiol can modulate the kinetics of endothelial progenitor cells (EPCs) via endothelial nitric oxide synthase (eNOS)-dependent mechanisms. We… (More)

IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression.

Johnson Rajasingh, Evelyn Bord, +8 authors Raj Kishore
FASEB journal : official publication of the…
2006

Inflammation plays an essential role in vascular injury and repair. Mononuclear phagocytes are important contributors in these processes, in part, via adhesive interactions and secretion of… (More)

Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.

Hiromichi Hamada, Myeong Kon Kim, +12 authors Douglas W. Losordo
Circulation
2006

BACKGROUND Estradiol (E2) modulates the kinetics of circulating endothelial progenitor cells (EPCs) and favorably affects neovascularization after ischemic injury. However, the roles of estrogen… (More)

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