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Three in vitro methods for the prediction of the skin sensitization hazard have been validated. However, predicting sensitizer potency is a key requirement for risk assessment. Here, we report a database of 312 chemicals tested in the KeratinoSens™ assay and for kinetic peptide binding. These data were used in multiple regression analysis against potency in(More)
Prohaptens are chemicals, which may cause skin sensitization after being converted into electrophilic molecules by skin enzymes. Aroclor-induced rat liver S9 fractions represent the metabolic activation system most commonly used in in vitro toxicology. This system contains much higher enzyme activities compared with those reported in skin, but it may still(More)
The skin sensitization potency of chemicals is partly related to their reactivity to proteins. This can be quantified as the rate constant of the reaction with a model peptide, and a kinetic profiling approach to determine rate constants was previously proposed. A linear relationship between the skin sensitization potency in the local lymph node assay(More)
  • CollaborationN. M. Agababyan, I. V. Ajinenko, +21 authors S. A. Zotkin
Bose-Einstein correlations are studied between negatively charged particles , in diierent reference frames of + p-interactions at 250 GeV/c. It is shown that there is no unique frame, where the pion source is motionless for each + p-collision, i.e. where the space-time size of the source is deenitely smaller than in any other frame. The emitting region has(More)
The Multiplicity distribution of all charged particles, as well as that of negatives and positives taken separately have been tted by a number of recently proposed parametrizations. The Negative Binomial (2 parameters) and Laguerre Distribution (3 parameters), in general, give good and very similar ts, but one of the parameters of the Laguerre distribution(More)