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These studies were conducted to localize the antinociceptive action of nicotine within the CNS. Antinociceptive and biodispositional studies were carried out after the injection of [3H]nicotine subcutaneously and intracerebroventricularly into the common carotid and vertebral arteries and into the subarachnoid space. The data indicated that [3H]nicotine was(More)
1. The aim of this study was to investigate post-synaptic reciprocal Ia inhibition during the stretch reflex; particularly the extent to which an increased Ia excitation of the Ia inhibitory interneurones will be counteracted by recurrent inhibition from motor axon collaterals. For this purpose we investigated depression of monosynaptic test reflexes(More)
The purpose of the present study was to map systematically in the thalamus the distribution of neurons processing nociceptive information from the tail of the rat. Pentobarbital-anesthetized and gallamine-paralyzed rats were used. Glass microelectrodes were used to record extracellularly from thalamic neurons. Noxious radiant heat stimuli were applied to(More)
Seven stable nitroxides have been evaluated as contrast agents in MRI studies of the rat cerebroventricular system. Because the contrast enhancement is primarily confined to the cerebral ventricles, nitroxides can be used to examine the ventricular structure. On the other hand, based on the absence of reducing agents in the rat CSF and on the fact that(More)
Both excitation and inhibition has been found in cells of origin of the ventral spino-cerebellar tract (VSCT) to be evoked by volleys in cortico-spinal fibres. The earliest EPSPs and IPSPs had features of disynaptically evoked postsynaptic potentials; these were, however, found only in a small proportion of cells and polysynaptic EPSPs and IPSPs were(More)
The rejection of [beta-125I]endorphin and D-[3H]Ala2-Met-enkephalinamide into the lateral ventricles of mice revealed that radioactivity could be transported rapidly via the cerebrospinal fluid (CSF) down to the lowest part of the spinal cord. The maximal levels of both compounds in thoracic, lumbar and sacral sections of the spinal cord occurred 10 min(More)
The sensitivity of muscle spindles in gastrocnemius-soleus (GS) muscles following dorsal root (DR) antidromic stimulation (ASt) was investigated in anesthetized rats, in which the hindleg was totally denervated except the GS muscle, ventral roots from L3 to S1 and DRs from L4 to L6, which were severed after laminectomy. The peripheral end of a teased DR(More)
A versatile in vivo canine model is indispensable in studying the phonation function of the larynx. In this study, we attempted to build an in vivo phonation model in anesthetized dogs using stereotaxic electrical stimulation at a specific area in the midbrain. In each of the eight animals in this experiment, evoked phonation was successfully elicited by(More)