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In data centers, the IO path to storage is long and complex. It comprises many layers or "stages" with opaque interfaces between them. This makes it hard to enforce end-to-end policies that dictate a storage IO flow's performance (e.g., guarantee a tenant's IO bandwidth) and routing (e.g., route an untrusted VM's traffic through a sanitization middlebox).(More)
For commissioning a linear accelerator for clinical use, medical physicists are faced with many challenges including the need for precision, a variety of testing methods, data validation, the lack of standards, and time constraints. Since commissioning beam data are treated as a reference and ultimately used by treatment planning systems, it is vitally(More)
Dynamic capacity provisioning is a well studied approach to handling gradual changes in data center load. However, abrupt spikes in load are still problematic in that the work in the system rises very quickly during the setup time needed to turn on additional capacity. Performance can be severely affected even if it takes only 5 seconds to bring additional(More)
<i>TetriSched</i> is a scheduler that works in tandem with a calendaring reservation system to continuously re-evaluate the immediate-term scheduling plan for all pending jobs (including those with reservations and best-effort jobs) on each scheduling cycle. <i>TetriSched</i> leverages information supplied by the reservation system about jobs' deadlines and(More)
PURPOSE Non-small-cell lung cancer (NSCLC) with pleural spread is incurable, with median survival rates ranging from 6 to 9 months. Surgery alone fails to locally control this disease or extend survival beyond the accepted treatment, palliative chemotherapy. METHODS We conducted a phase II trial to evaluate the effects on local control and survival of(More)
PURPOSE A previous phase I trial of i.p. photodynamic therapy established the maximally tolerated dose of Photofrin (Axcan Pharma, Birmingham, AL)-mediated photodynamic therapy and showed encouraging efficacy. The primary objectives of this phase II study were to determine the efficacy and toxicities of i.p. photodynamic therapy in patients with peritoneal(More)
Meeting service level objectives (SLOs) for tail latency is an important and challenging open problem in cloud computing infrastructures. The challenges are exacerbated by burstiness in the workloads. This paper describes PriorityMeister -- a system that employs a combination of per-workload priorities and rate limits to provide tail latency QoS for shared(More)
The contribution from contaminant electrons in the buildup region of a photon beam must be separated when calculating the dose using a photon convolution kernel. Their contribution can be extrapolated from fractional depth dose (FDD) data using the fractional depth kerma (or the "equilibrium dose") derived from measured quantities such as beam attenuation(More)
Singlet oxygen ((1)O(2)) is the major cytotoxic agent responsible for cell killing for type-II photodynamic therapy (PDT). An empirical four-parameter macroscopic model is proposed to calculate the "apparent reacted (1)O(2) concentration", [(1)O(2)](rx), as a clinical PDT dosimetry quantity. This model incorporates light diffusion equation and a set of PDT(More)
BACKGROUND Photodynamic therapy (PDT) is a light-based cancer treatment that, in the correct setting, can be delivered intraoperatively as an adjuvant therapy. A phase I clinical trial combining surgical debulking with Foscan-mediated PDT was performed in patients with malignant pleural mesothelioma. The purpose of the study was to define the toxicities and(More)