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For commissioning a linear accelerator for clinical use, medical physicists are faced with many challenges including the need for precision, a variety of testing methods, data validation, the lack of standards, and time constraints. Since commissioning beam data are treated as a reference and ultimately used by treatment planning systems, it is vitally(More)
Photodynamic therapy (PDT) can lead to the creation of heterogeneous, response-limiting hypoxia during illumination, which may be controlled in part through illumination fluence rate. In the present report we consider (1) regional differences in hypoxia, vascular response, and cell kill as a function of tumor depth and (2) the role of fluence rate as a(More)
In data centers, the IO path to storage is long and complex. It comprises many layers or "stages" with opaque interfaces between them. This makes it hard to enforce end-to-end policies that dictate a storage IO flow's performance (e.g., guarantee a tenant's IO bandwidth) and routing (e.g., route an untrusted VM's traffic through a sanitization middlebox).(More)
PURPOSE A previous phase I trial of i.p. photodynamic therapy established the maximally tolerated dose of Photofrin (Axcan Pharma, Birmingham, AL)-mediated photodynamic therapy and showed encouraging efficacy. The primary objectives of this phase II study were to determine the efficacy and toxicities of i.p. photodynamic therapy in patients with peritoneal(More)
A thorough understanding of optical properties of biological tissues is critical to effective treatment planning for therapies such as photodynamic therapy (PDT). In the last two decades, new technologies, such as broadband diffuse spectroscopy, have been developed to obtain in vivo data in humans that was not possible before. We found that the in vivo(More)
The views and conclusions contained in this document are those of the author and should not be interpreted as representing the official policies, either expressed or implied, of any sponsoring institution, the U.S. government or any other entity. Abstract Dynamic capacity provisioning is a well studied approach to handling gradual changes in data center(More)
<i>TetriSched</i> is a scheduler that works in tandem with a calendaring reservation system to continuously re-evaluate the immediate-term scheduling plan for all pending jobs (including those with reservations and best-effort jobs) on each scheduling cycle. <i>TetriSched</i> leverages information supplied by the reservation system about jobs' deadlines and(More)
BACKGROUND A study was needed to determine the effect of primary tumor volume on local control of oropharyngeal carcinoma treated with radiation therapy, with or without induction chemotherapy. METHODS Between July 1983 and April 1995, 114 patients with T2-T4 squamous cell carcinoma of the oropharynx were treated for cure with radiation therapy, with or(More)
BACKGROUND Photodynamic therapy (PDT) is a light-based cancer treatment that, in the correct setting, can be delivered intraoperatively as an adjuvant therapy. A phase I clinical trial combining surgical debulking with Foscan-mediated PDT was performed in patients with malignant pleural mesothelioma. The purpose of the study was to define the toxicities and(More)