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A slow progressive death of neurons is the hallmark of neurodegenerative diseases, such as glaucoma. A therapeutic candidate, erythropoietin (EPO), has shown promise in many models of these diseases; however, it also causes polycythemia, a potentially lethal side effect. We have developed a novel mutant form of EPO that is neuroprotective but no longer(More)
We present a case study of our experience designing SellTrend, a visualization system for analyzing airline travel purchase requests. The relevant transaction data can be characterized as multi-variate temporal and categorical event sequences, and the chief problem addressed is how to help company analysts identify complex combinations of transaction(More)
Activation of peroxisome proliferator-activated receptor-γ (PPARγ) inhibits growth of cancer cells including non-small cell lung cancer (NSCLC). Clinically, use of thiazolidinediones, which are pharmacological activators of PPARγ is associated with a lower risk of developing lung cancer. However, the role of this pathway in lung cancer metastasis has not(More)
We have reported the production of white adipocytes in adipose tissue from hematopoietic progenitors arising from bone marrow. However, technical challenges have hindered detection of this adipocyte population by certain other laboratories. These disparate results highlight the need for sensitive and definitive techniques to identify bone marrow progenitor(More)
We present foundational work on the use of niche modeling to predict continuous surfaces of acid neutralizing capacity (ANC) and base cation weathering (BC w) within the southern Appalachian Mountain Region of the United States. Predicted ANC and BC w surfaces are subsequently used to estimate steady-state critical loads (CLs) of atmospheric sulfur(More)
Estuaries and coastal areas contain increasingly exploited resources that need to be monitored, managed and protected efficiently and effectively. This requires access to reliable and timely data and management decisions must be based on analysis of collected data to avoid or limit negative impacts. Visually supported multi-modal sensing and data fusion(More)
BACKGROUND Pulmonary vascular remodeling in pulmonary hypertension (PH) is characterized by increased vascular smooth muscle cell (SMC) and adventitial fibroblast proliferation, small vessel occlusion, and inflammatory cell accumulation. The underlying molecular mechanisms driving progression remain poorly defined. We have focused on loss of the phosphatase(More)
TO THE EDITOR—In their recent study, Baranoski et al [1] describe a high rate of liver disease progression in patients with human immunodeficiency virus (HIV)-hepatitis B virus coinfection and CD4 counts <200 cells/mm 3. The authors suggest that more advanced immunosup-pression in these patients may lead to accelerated liver fibrosis. Because only 50% of(More)