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  • Shihao Chen, Li-Fen Lee, +12 authors John C. Lin
  • Medicine, Biology
  • Cancer Immunology Research
  • 2014 (First Publication: 11 November 2014)
  • Chen, Lee, and colleagues compared the antitumor activity of anti-PD-1 in combination with anti-4-1BB versus with anti-LAG-3 and showed in syngeneic, poorly immunogenic mouse tumor models that theExpand
  • Timothy S Fisher, Cris Kamperschroer, +10 authors Leslie Lynne Sharp
  • Biology, Medicine
  • Cancer Immunology, Immunotherapy
  • 2012 (First Publication: 11 March 2012)
  • Abstract4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed on several subsets of activated immune cells. Numerous studies of mouse and human T cells indicate that 4-1BB promotes cellularExpand
  • Terence R. S. Ozolinš, Timothy S Fisher, +7 authors Baiyong Li
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2009 (First Publication: 18 December 2009)
  • The HIF (hypoxia inducible factor) hydroxylases EGNL1/PHD2 has been implicated in embryonic development. Here we knocked down EGNL1 in vivo by injecting one-cell murine zygotes withExpand
  • Timothy S Fisher, Andrea T. Hooper, +13 authors Chad May
  • Medicine, Biology
  • Cancer Immunology, Immunotherapy
  • 2017 (First Publication: 1 February 2018)
  • Strong evidence exists supporting the important role T cells play in the immune response against tumors. Still, the ability to initiate tumor-specific immune responses remains a challenge. RecentExpand