Timothy R. Angeli

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  Gastrointestinal extracellular recordings have been a core technique in motility research for a century. However, the bioelectrical basis of extracellular data has recently been challenged by claims that these techniques preferentially assay movement artifacts, cannot reproduce the underlying slow wave kinetics, and misrepresent the true slow wave(More)
Figure. The morphology of suction extracellular slow wave potentials (A) approximates intracellular slow wave recordings, while their second derivative (C) appropriately approximates the morphology of potentials recorded by conventional contact extracellular electrodes (D). Adapted from Angeli et al. 4 TO THE EDITOR: We read with interest the paper by Worth(More)
BACKGROUND Gastrointestinal contractions are controlled by an underlying bioelectrical activity. High-resolution spatiotemporal electrical mapping has become an important advance for investigating gastrointestinal electrical behaviors in health and motility disorders. However, research progress has been constrained by the low efficiency of the data analysis(More)
Motility of the stomach is in part coordinated by an electrophysiological event called slow waves, which are generated by pacemaker cells called the interstitial cells of Cajal (ICC). In functional motility disorders, which can be associated with a reduction of ICC, dynamic slow wave dysrhythmias can occur. In recent years, high-resolution (HR) mapping(More)
We present a novel, fully-automated gastrointestinal spike burst detection algorithm. Following pre-processing with SALPA (Wagenaar and Potter, J. Neurosci. Methods 120:113–120, 2002) and a Savitzky–Golay filter to remove unwanted low and high frequency components, candidate spike waveforms are detected utilizing the non-linear energy operator. Candidate(More)
BACKGROUND/AIMS Small intestine motility is governed by an electrical slow wave activity, and abnormal slow wave events have been associated with intestinal dysmotility. High-resolution (HR) techniques are necessary to analyze slow wave propagation, but progress has been limited by few available electrode options and laborious manual analysis. This study(More)
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