Timothy R. Angeli

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Cycling by means of functional electrical stimulation (FES) is an attractive training method for individuals with paraplegia. The physiological benefits of FES are combined with the psychological incentive of independent locomotion. In addition, cycling has the advantage in that the generated muscle forces are converted into drive power with relatively high(More)
OBJECTIVES To compare the skeletal benefits associated with gymnastics between ulna and radius. METHODS 19 retired artistic gymnasts, aged 18-36 years, were compared to 24 sedentary women. Bone mineral content (BMC), total and cortical bone area (ToA, CoA), trabecular and cortical volumetric density (TrD, CoD) and cortical thickness (CoTh) were measured(More)
BACKGROUND Gastrointestinal contractions are controlled by an underlying bioelectrical activity. High-resolution spatiotemporal electrical mapping has become an important advance for investigating gastrointestinal electrical behaviors in health and motility disorders. However, research progress has been constrained by the low efficiency of the data analysis(More)
  Gastrointestinal extracellular recordings have been a core technique in motility research for a century. However, the bioelectrical basis of extracellular data has recently been challenged by claims that these techniques preferentially assay movement artifacts, cannot reproduce the underlying slow wave kinetics, and misrepresent the true slow wave(More)
BACKGROUND Gastric slow waves propagate aborally as rings of excitation. Circumferential propagation does not normally occur, except at the pacemaker region. We hypothesized that (i) the unexplained high-velocity, high-amplitude activity associated with the pacemaker region is a consequence of circumferential propagation; (ii) rapid, high-amplitude(More)
BACKGROUND/AIMS Small intestine motility is governed by an electrical slow wave activity, and abnormal slow wave events have been associated with intestinal dysmotility. High-resolution (HR) techniques are necessary to analyze slow wave propagation, but progress has been limited by few available electrode options and laborious manual analysis. This study(More)
TO THE EDITOR: In their recent review " Interstitial cells: regulators of smooth muscle function, " Sanders, Ward, and Ko offer a comprehensive perspective on the features and functions of interstitial cells (11). However, several of the au-thors' claims in their discussion of gastrointestinal extracel-lular recordings (Section II.E.1) require rebuttal,(More)
Figure. The morphology of suction extracellular slow wave potentials (A) approximates intracellular slow wave recordings, while their second derivative (C) appropriately approximates the morphology of potentials recorded by conventional contact extracellular electrodes (D). Adapted from Angeli et al. 4 TO THE EDITOR: We read with interest the paper by Worth(More)
BACKGROUND Slow-waves modulate the pattern of small intestine contractions. However, the large-scale spatial organization of intestinal slow-wave pacesetting remains uncertain because most previous studies have had limited resolution. This study applied high-resolution (HR) mapping to evaluate intestinal pacesetting mechanisms and propagation patterns in(More)
BACKGROUND AND AIMS High-frequency gastric electrical stimulation (GES) has emerged as a therapy for gastroparesis, but the mechanism(s) of action remain unclear. There is a need to refine stimulation protocols for clinical benefit, but a lack of accurate techniques for assessing mechanisms in clinical trials, such as slow wave modulation, has hindered(More)