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Detecting latitudinal range shifts of forest trees in response to recent climate change is difficult because of slow demographic rates and limited dispersal but may be facilitated by spatially compressed climatic zones along elevation gradients in montane environments. We resurveyed forest plots established in 1964 along elevation transects in the Green(More)
Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release of IL-1β, IL-6, IL-8, and Vascular Endothelial Growth(More)
In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we investigated lung epithelial cells as a target for(More)
Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory protein TRX-interacting protein link oxidative stress with inflammasome activation. We investigated inflammasome activation by crystalline silica(More)
Exposure to respirable crystalline silica particles, as opposed to amorphous silica, is associated with lung inflammation, pulmonary fibrosis (silicosis), and potentially with lung cancer. We used Affymetrix/GeneSifter microarray analysis to determine whether gene expression profiles differed in a human bronchial epithelial cell line (BEAS 2B) exposed to(More)
In this paper, we demonstrate reliable navigation of a smart wheelchair system (SWS) in an urban environment. Urban environments present unique challenges for service robots. They require localization accuracy at the sidewalk level, but compromise GPS position estimates through significant multi-path effects. However , they are also rich in landmarks that(More)
This paper presents the preliminary design of the integrated stimulator and telemetry subsystems for a vestibular prosthesis to restore balance function. The work is part of the European project CLONS. The stimulator is designed to provide biphasic current pulses at specified amplitude, duration and rate to stimulate the semicircular canals in the(More)
BACKGROUND Exposures to an amphibole fiber in Libby, Montana cause increases in malignant mesothelioma (MM), a tumor of the pleural and peritoneal cavities with a poor prognosis. Affymetrix microarray/GeneSifter analysis was used to determine alterations in gene expression of a human mesothelial cell line (LP9/TERT-1) by a non-toxic concentration (15×10(6)(More)
Although many analyses of the chemical composition of maple syrup have been conducted, relatively little information exists on the differences in composition of the individual syrup grades. For example, although it is generally accepted that the amount of invert sugar increases with decreasing syrup light transmission (from lighter to darker grades), the(More)