Timothy Madden

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Glioma stem-like cells (GSCs) may be the initiating cells in glioblastoma (GBM) and contribute to the resistance of these tumors to conventional therapies. Development of novel chemotherapeutic agents and treatment approaches against GBM, especially those specifically targeting GSCs are thus necessary. In the present study, we found that a novel Janus(More)
We present a novel use of the OpenSound Control (OSC) protocol to represent the output of gestural controllers as well as the input to sound synthesis processes. With this scheme, the problem of mapping gestural input into sound synthesis control becomes a simple translation from OSC messages into other OSC messages. We provide examples of this strategy and(More)
PURPOSE To determine the dose-limiting toxicity and maximum-tolerated dose of the proteasome inhibitor bortezomib administered intravenously weekly for 4 every 5 weeks; to determine the bortezomib pharmacokinetics and pharmacodynamics using plasma levels and an assay for 20S proteasome inhibition (PI) in whole blood; to correlate toxicity with bortezomib(More)
This paper describes the design, implementation, and use of an interactive computer-based instrument in the context of a composition for orchestra and live electronics. We will begin with an overview of the piece from a compositional point of view, emphasizing the musical goals for the electronics aspect. Then we will discuss the extremely demanding(More)
Allodynia, a painful response to a usually nonpainful stimulus, is common in chronic migraine. The evaluation of allodynia can be important clinically. Dynamic mechanical allodynia (brush) testing has been shown to be both a simple and reliable way to evaluate allodynia. In this study, we show that self-administered brush allodynia testing at home is a(More)
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