Timothy M Fan

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Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group.

Robert E Goldsby, Timothy M Fan, +10 authors Neyssa M Marina
European journal of cancer
2013

AIM Patients with metastatic osteosarcoma (OS) have a poor outcome with conventional therapies. Zoledronic acid (ZA) is a third-generation bisphosphonate that reduces skeletal-related events in many… (More)

Selective in vivo metabolic cell-labeling-mediated cancer targeting.

Hua Wang, Ruibo Wang, +18 authors Jianjun Cheng
Nature chemical biology
2017

Distinguishing cancer cells from normal cells through surface receptors is vital for cancer diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a powerful tool to… (More)

Evaluating the Clinical and Physiological Effects of Long Term Ultraviolet B Radiation on Guinea Pigs (Cavia porcellus)

Megan K. Watson, Adam W. Stern, +6 authors Mark A. Mitchell
PloS one
2014

Vitamin D is an important hormone in vertebrates. Most animals acquire this hormone through their diet, secondary to exposure to ultraviolet B (UVB) radiation, or a combination thereof. The… (More)

Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A

Li Tang, Jamil R. Azzi, +8 authors Jianjun Cheng
Journal of transplantation
2012

We encapsulated cyclosporine A (CsA) in poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PEG-PLGA) nanoparticles (NPs) by nanoprecipitation of CsA and PEG-PLGA. The resulting CsA/PEG-PLGA-NPs… (More)

Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates.

Li Tang, Timothy M Fan, Luke B. Borst, Jianjun Cheng
ACS nano
2012

Drug-containing nanoparticles (NPs) with monodisperse, controlled particle sizes are highly desirable for drug delivery. Accumulating evidence suggests that NPs with sizes less than 50 nm demonstrate… (More)

Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates.

Li Tang, Nathan P. Gabrielson, Fatih M. Uckun, Timothy M Fan, Jianjun Cheng
Molecular pharmaceutics
2013

The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall… (More)

Investigating the optimal size of anticancer nanomedicine.

Li Tang, Xujuan Yang, +15 authors Jianjun Cheng
Proceedings of the National Academy of Sciences…
2014

Nanomedicines (NMs) offer new solutions for cancer diagnosis and therapy. However, extension of progression-free interval and overall survival time achieved by Food and Drug Administration-approved… (More)

Single-agent pamidronate for palliative therapy of canine appendicular osteosarcoma bone pain.

Timothy M Fan, Louis-Philippe de Lorimier, Kristen J O'Dell-Anderson, Hugues I Lacoste, Sarah C Charney
Journal of veterinary internal medicine
2007

BACKGROUND Canine appendicular osteosarcoma (OSA) causes focal bone destruction, leading to chronic pain and reduced quality-of-life scores. Drugs that inhibit pathologic osteolysis might provide… (More)

Bisphosphonates and cancer.

Rowan J Milner, James P. Farese, C Jeyakumar K Henry, Kim A. Selting, Timothy M Fan, Louis-Philippe de Lorimier
Journal of veterinary internal medicine
2004

Bisphosphonates form a family of drugs characterized pharmacologically by their ability to inhibit bone resorption and pharmacokinetically by similar intestinal absorption, skeletal distribution, and… (More)

The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells.

Rong Tong, Linda Yala, Timothy M Fan, Jianjun Cheng
Biomaterials
2010

Paclitaxel-polylactide (Ptxl-PLA) conjugate nanoparticles, termed as nanoconjugates (NCs), were prepared through Ptxl/(BDI)ZnN(TMS)(2) (BDI =… (More)

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