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Earlier studies have suggested that patients with slow acetylation phenotype were more likely to respond to phenelzine treatment and more likely to experience side effects. The metabolism of phenelzine has not been extensively investigated in humans because of limitations in analytical methodology. A labeled form of phenelzine is required for metabolite(More)
Researchers at the National Institute for Occupational Safety and Health (NIOSH) are investigating different lighting technologies with the objective of improving mine safety. This paper presents the results from an ongoing study that compares discomfort glare for different light-emitting diode (LED) cap lamps using the de Boer glare rating scale. The cap(More)
Cocaine disposition studies in the rat are described. A mixture of cocaine, cocaine-d3, cocaine-14C, and cocaine-3H was used as a dose. The urine was collected, extracted with organic solvents, and fractions collected using HPLC and TLC. The radioactive cocaine was useful in the separation of metabolites while the deuterium-labeled cocaine, creating an(More)
Ion cluster technique in conjunction with gas chromatography-mass spectrometry (GC-MS) was used for the identification and quantitation of major metabolites of cocaine (1a) in rat and humans. In a typical experiment, a female rat weighing 250 gm was intraperitoneally administered a 20-mg/kg mixture of 1a, NCD3-cocaine (1b), OCD3-cocaine (1c), and(More)
A gas chromatographic mass spectrometric assay has been developed for the determination of cocaine and its pharmacologically active metabolite, norcocaine, in human urine. [2H3]Cocaine and [2H3]norcocaine were used as internal standards. The assay utilizes selective focusing to monitor in a gas chromatographic effluent the molecular ions of cocaine,(More)
Ten sets of 5 littermate pigs from each of 2 genetic strains were utilized to determine the impact of the dietary concentration of 5 B vitamins (riboflavin, niacin, pantothenic acid, cobalamin, and folacin) on growth from 9 to 28 kg of BW in pigs with high or moderate capacity for lean growth. All pigs (penned individually) were reared via a segregated,(More)
Miners depend most heavily on visual cues to recognize underground mining hazards; consequently, illumination plays a critical role in miners' safety. Some hazards are located in the miners' peripheral field of view (10° to about 60° off axis) or on axis (0°). The objective of this research was to determine if there were visual(More)
We have performed NMR spin-lattice relaxation experiments and molecular dynamics (MD) computer simulations on atactic polystyrene (a-PS). The segmental correlation times of three different molecular weight a-PS (Mn) 1600, 2100, 10 900 g/mol) were extracted from NMR by measuring the 2 H spin-lattice relaxation times (T1) over a broad temperature range(More)
A quantitative gas liquid chromatographic-mass spectrometric (GLC/MS) assay was developed for the determination of loxapine in human blofluids and tissues. The assay utilizes selected ion monitoring in a GLC effluent of the molecular ion of loxapine generated by electron-impact ionization (EI). Loxapine-d3 was used as the internal standard. The assay can(More)