Timothy Laszlo Frank

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BACKGROUND Many environmental factors have been investigated to determine their involvement in the asthma epidemic. OBJECTIVE We sought to investigate the indoor environment of English children. METHOD The Indoor Pollutants, Endotoxin, Allergens, Damp and Asthma in Manchester (IPEADAM) study recruited 200 asthmatic and age-, sex-, and sibship(More)
BACKGROUND Comorbidity is common. National Institute for Health and Clinical Excellence (NICE) guidelines have been created to make best use of resources to improve patients' quality of life but do not currently take account of comorbidity. The effect of multiple chronic conditions with regard to health-related quality of life (HRQoL) is poorly researched.(More)
OBJECTIVES To describe nurse-led UK general practice asthma and chronic obstructive pulmonary disease (COPD) care, and the training undertaken to support it. METHODS Questionnaires were sent to 500 randomly-selected UK asthma and COPD practice nurses. RESULTS 382 nurses (76%) completed the practice characteristics section, 389 (78%) described their(More)
UNLABELLED Children spend increasing time indoors. Exposure to environmental factors may contribute to the development or exacerbation of the asthmatic phenotype. Inter-relationships between these factors might influence the manifestation of asthma. Endotoxin exposure has been shown to have pro-inflammatory and protective effects in different situations. We(More)
The aim of the present study was to validate a simple scoring system using a parent-completed screening questionnaire to identify children aged 5-15 yrs who may have asthma. A stratified random sample of 157 children of 1,808 whose parents had answered a postal respiratory questionnaire underwent detailed clinical evaluation. The results were reviewed by(More)
PURPOSE To use a neural network to rank a population according to individual likelihood of asthma based on their responses to a respiratory questionnaire. METHODS A final diagnosis of asthma can be made only after full clinical assessment but limited resources make it impossible to offer this to complete populations as part of a screening programme.(More)
BACKGROUND Although it is recognised that smoking is a major risk factor for subjects with chronic obstructive pulmonary disease and is associated with respiratory symptoms, there is less agreement concerning the relationship between asthma and smoking. This study aims to examine the relationship between cigarette smoking and asthma prevalence. METHOD(More)
BACKGROUND The Manchester Community Asthma Study (MANCAS) found a protective effect against the risk of wheeze at age 6 to 11 years for children given neonatal BCG vaccination. Our subsequent systematic review and meta-analysis suggested that BCG vaccination did not protect against allergic sensitization but might have exerted a protective effect against(More)
BACKGROUND There has been little available information regarding secular changes in the prevalence of respiratory symptoms since the mid-1990s. AIM To examine changes in the prevalence of respiratory symptoms for 1993-2001. DESIGN OF STUDY A series of postal questionnaire surveys. SETTING Two general practice populations, including all age groups. (More)
BACKGROUND In order to assess and plan for changing healthcare needs, the lack of available information regarding temporal changes in the health-related quality of life of a population must be addressed. AIM This paper aims to describe such changes over 5 years in a general population. DESIGN OF STUDY Longitudinal postal questionnaire study. SETTING(More)