Timothy L Schneider

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Various concentrations of three dopamine antagonists (fluphenazine, haloperidol and sulpiride) with different affinities to the receptor subtypes were applied in order to test their effect on responses from outer (isolated PIII-component of the ERG), middle (b-wave) and inner (optic nerve response, ONR) retinal layers, recorded from dark-adapted, isolated,(More)
The purpose of this study was to establish the accuracy of ultrasound in the examination of the plantar plate by comparing it with MRI, or if available, surgical findings. The lesser metatarsophalangeal joint plantar plates of 40 symptomatic and 40 asymptomatic feet (160 asymptomatic and 160 symptomatic plantar plates) were examined with ultrasound and MRI.(More)
OBJECTIVE The purpose of our study was to describe the sonographic appearance of the lesser metatarsal plantar plates in cadavers and to correlate these findings with MRI and histology. MATERIALS AND METHODS Six soft-embalmed cadaveric feet (74-92 years old; two male, one female) were imaged with sonography and MRI. Tear dimensions of the plantar plate(More)
Jurkat T-lymphocytes lack p53 and Bax but contain p73 and Bid and are killed by etoposide (ETO). With ETO c-abl is phosphorylated and phosphorylated p73 increased. Translocation of full-length Bid to mitochondria follows, with induction of the mitochondrial permeability transition (MPT) and release of cytochrome c into the cytosol. Pronounced swelling of(More)
In Jurkat cells Bid was cleaved upon activation of the Fas receptor with an anti-Fas antibody. The caspase-8 inhibitor benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-CH(2)F (IETD) prevented the cleavage of Bid and the loss of viability. The nuclear enzyme poly(ADP-ribose)polymerase (PARP) was also cleaved upon the activation of caspases, and IETD similarly(More)
PURPOSE To analyze patient results after laser-assisted subepithelial keratectomy (epi-LASEK) for myopia and myopic astigmatism. SETTING Private practice setting, Columbus, Ohio, USA. METHODS Three hundred forty-three eyes of 188 patients with myopia or myopic astigmatism were prospectively evaluated after having epi-LASEK by a single surgeon using the(More)
The off-response of dark adapted cat ganglion cells shows a tripartite response-intensity function in the optic nerve response (ONR) as well as in extracellular recordings of single cells. While responses increase when stimuli of low or high intensities are increased, the rod driven off-response shows a strong decrease (dip) for intermediate intensities(More)
Stimulating the isolated arterially perfused cat eye with two consecutive flashes (double flashes) we have studied the reduction of the 2nd response recorded from outer (isolated PIII component of the ERG), middle (b-wave) and inner (optic nerve response, ONR) retinal layers. The spectral sensitivity of the mechanism that reduces the amplitude of the 2nd(More)
PURPOSE To determine whether surgeon-specific nomogram adjustments are useful when using the Technolas 217A excimer laser for treating myopia and myopic astigmatism. METHODS We conducted a prospective evaluation of 216 consecutive eyes with 6 months follow-up after treatment of myopia or myopic astigmatism with the Technolas 217A laser. Attempted vs.(More)
Metatarsalgia is a common problem for many in the community. The condition includes many different entities, such as interdigital neuroma, synovitis or metatarsophalangeal joint instability, Freiberg infarction, stress fractures, and systemic disorders. Many patients presenting with metatarsalgia have a combination of diagnostic abnormalities. The key is to(More)