Timothy Hayes

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The terminal differentiation of neurons occurs as precisely timed waves, with specific neuronal types differentiating in defined sequences. The precision of neuronal differentiation in the central nervous system offers an unusual opportunity to study terminal differentiation in vivo. The p34cdc2 kinase complex and the anti-oncogenes p53 and RB are central(More)
This paper describes an innovative multiagent system called SAVES with the goal of conserving energy in commercial buildings. We specifically focus on an application to be deployed in an existing university building that provides several key novelties: (i) jointly performed with the university facility management team, SAVES is based on actual occupant(More)
Sustainable energy domains have become extremely important due to the significant growth in energy usage. Building multiagent systems for real-world energy applications raises several research challenges regarding scalability, optimizing multiple competing objectives , model uncertainty, and complexity in deploying the system. Motivated by these challenges,(More)
Research on consumer decision making has long recognized the influence of others. In this comment on Simpson, Griskevicius, and Rothman (this issue), we agree with them that consumer decisions are best understood in the social contexts in which these decisions are made. We explain how research on consumer social influence incorporates social motives, and we(More)
(2). bHLH transcription factors are known to play an important role in the regulation of cell determination and differentiation in several cell-specific lineages as well as in cell proliferation and transforma tion. However, Id proteins lack the basic amino acid domain necessary for DNA binding and inhibit binding to DNA and transcriptional activation by(More)
In the developing brain, neurons are derived from multipotential precursor cells in a precise sequence, where the time when a neuron becomes postmitotic is closely linked to the differentiated function of the neuron. Work from our group (1) identifies the Nes+ neuronal precursor state, (2) defines growth factors that regulate the proliferation of Nes+(More)
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