Timothy H. Ciesielski

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BACKGROUND Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes. OBJECTIVE Our aim was to evaluate associations between urinary cadmium concentration and reported learning disability (LD), special education utilization, and attention deficit hyperactivity disorder (ADHD) in U.S. children using(More)
BACKGROUND Low-level environmental cadmium exposure and neurotoxicity has not been well studied in adults. Our goal was to evaluate associations between neurocognitive exam scores and a biomarker of cumulative cadmium exposure among adults in the Third National Health and Nutrition Examination Survey (NHANES III). METHODS NHANES III is a nationally(More)
In omic research, such as genome wide association studies, researchers seek to repeat their results in other datasets to reduce false positive findings and thus provide evidence for the existence of true associations. Unfortunately this standard validation approach cannot completely eliminate false positive conclusions, and it can also mask many true(More)
BACKGROUND We sought to identify and characterize predictors of poor fetal growth among variables extracted from perinatal medical records to gain insight into potential etiologic mechanisms. In this process we reevaluated a previously observed association between poor fetal growth and maternal psychiatric disease. METHODS We evaluated 449 deliveries of(More)
It is clear that the public health community is concerned about the human health impacts of climate change, but are we inadvertently underestimating the scope of the problem and obfuscating potentially useful interventions by using a narrow intellectual frame in our discussions with policy makers? If we take a more holistic approach, we see that the public(More)
The primary goal of translational research is to generate and apply knowledge that can improve human health. Although research conducted within the confines of a single discipline has helped us to achieve this goal in many settings, this unidisciplinary approach may not be optimal when disease causation is complex and health decisions are pressing. To(More)
masks many true findings (but they are not found) Agreed. We have changed this to: “masks many true associations” Cofactors (do you mean covariates) Cofactor: meaning causal cofactor or component cause (e.g. biological factors that physically interact to generate pathogenic mechanisms). In one place we left the term co-factor to assure we gave this(More)
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