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Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity
ABSTRACT The HIV-1 envelope (Env) trimer is a target for vaccine design as well as a conformational machine that facilitates virus entry by transitioning between prefusion-closed, CD4-bound, andExpand
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Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
While the HIV-1-glycan shield is known to shelter Env from the humoral immune response, its quantitative impact on antibody elicitation has been unclear. Here, we use targeted deglycosylation toExpand
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Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.
Antigen multimerization on a nanoparticle can result in improved neutralizing antibody responses. A platform that has been successfully used for displaying antigens from a number of different virusesExpand
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Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen
The vaccine elicitation of broadly neutralizing antibodies against HIV-1 is a long-sought goal. We previously reported the amino-terminal eight residues of the HIV-1-fusion peptide (FP8) – whenExpand
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By It I See Everything Else: Founding Scientific Inquiry Upon God and His Word
Name: Timothy Wanninger Major: B.S. Biology, B.S. Biochemistry BY IT I SEE EVERYTHING ELSE: FOUNDING SCIENTIFIC INQUIRY UPON GOD AND HIS WORD Advisor’s Name: Dr. Kristi Penheiter Reader’s Name: Dr.Expand
The IMPDH inhibitor merimepodib provided in combination with the adenosine analogue remdesivir reduces SARS-CoV-2 replication to undetectable levels in vitro
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus responsible for the ongoing COVID-19 pandemic, which has resulted in over 2.5 million confirmed cases and 170,000Expand