Timothy Elkins

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Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes--more than twice as many as in the fission yeast Schizosaccharomyces pombe and only(More)
Drosophila fasciclin I is a homophilic cell adhesion molecule expressed in the developing embryo on the surface of a subset of fasciculating CNS axons, all PNS axons, and some nonneuronal cells. We have identified protein-null mutations in the fasciclin I (fas I) gene, and show that these mutants are viable and do not display gross defects in nervous system(More)
Fasciclin I is a membrane-associated glycoprotein that is regionally expressed on a subset of fasciculating axons during neuronal development in insects; it is expressed on apposing cell surfaces, suggesting a role in specific cell adhesion. In this paper we show that Drosophila fasciclin I is a novel homophilic cell adhesion molecule. When the nonadhesive(More)
OBJECTIVE This study was designed to determine whether the incidence of squamous cell carcinoma of the oral tongue (SCCOT) in young adults has changed during the past 25 years and to determine prognostic factors for young adult patients (aged < 40 years) with SCCOT. METHODS AND PATIENTS A retrospective review of young adults with SCCOT who sought(More)
A woman in labor and not wearing a seat belt sustained multiple fractures of the pelvis and femur while in an automobile accident. The fetus suffered fractures of the parietal and occipital bones. To minimize maternal pelvic and fetal injury, delivery by cesarean section was performed. The infant had generalized cerebral edema and intraventricular and(More)
Recent advances in the repair of nonobstetric fistulas include a tendency toward earlier repair attempts, use of ureteral stenting and endoscopic correction, and even the use of laparoscopy for fistula repair. There has also been an increased use of posthysterectomy cystoscopy for early identification of ureteral or bladder injury to prevent later fistula.(More)
The establishment of correct neuronal connections during development of the nervous system requires information both to guide growing axons and to ensure proper connections. In both vertebrates and invertebrates, it has been found that necessary guidance cues mediating interactions between axons and the environment can be provided by cell surface molecules(More)
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