Timothy Eggleston

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The node, or its zebrafish equivalent, Kupffers Vesicle (KV), is thought to generate laterality cues through cilia-dependent signaling. An interaction between Nodal ligands and Nodal antagonists around the node/KV is also required. Here we investigate whether loss of Brachyury/Notail or Tbx16/Spadetail disrupts the balance of Nodal ligands (Southpaw) and(More)
The graft-versus-host disease reaction is an immunologic consequence resulting from the grafting of immunocompetent cells from one individual to an immunocompromised host. The oral manifestations of this disease process include severe oral pain, xerostemia, ulcerative lesions, and mucositis. With appropriate history and diagnostic testing, these lesions can(More)
Dentigerous cysts are commonly encountered in the practice of dentistry and oral and maxillofacial surgery. Treatment modalities range from enucleation to marsupialization, and are based on the premise that the pathological process can be controlled locally with minimal injury to the adjacent host structures. In a child, however, loss of permanent tooth(More)
TNF-alpha influences morbidity and mortality during the course of endotoxemia. However, the complex pleiotropic functions of TNF-alpha remain poorly understood. We evaluated how hepatic induction of NF-kappaB and TNF-alpha influence survival and hepatocellular death in a lethal murine model of endotoxic shock. Using dominant-negative viral vectors to(More)
Fractures of the zygomatic complex and their treatment have been the focus of much attention in the last 30 years. Treatment frequently depends on the surgical findings, experience, and discretion of the surgeon. Treatment of zygomatic complex (ZMC) fractures often requires stabilization at the frontozygomatic (FZ) suture. Frodel’ and Marentette’ have(More)
Rana Dajani, Salih Sanlioglu, Yulong Zhang, Qiang Li, Martha M. Monick, Eric Lazartigues, Timothy Eggleston, Robin L. Davisson, Gary W. Hunninghake, and John F. Engelhardt Department of Anatomy and Cell Biology, Department of Internal Medicine-Division of Pulmonary and Critical Care, Center for Gene Therapy at the University of Iowa College of Medicine,(More)
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