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Four different pancreatin products, Pancrease, Creon, Pancrex V Forte, and Pancreatin Merck, were compared in a random crossover trial in children with cystic fibrosis. The results of our study showed that patients who received Creon and Pancrease had fewer gastrointestinal symptoms than patients who received Pancrex V Forte and Pancreatin Merck. Fat… (More)
BACKGROUND Catheter-tissue contact force (CF) determines radiofrequency (RF) ablation lesion size. Impedance changes during RF delivery are used as surrogate markers for CF. The relationship between impedance and real-time CF in humans remains unknown. OBJECTIVES To determine whether impedance changes have predictive value for real-time CF during catheter… (More)
Acquired pulmonary stenosis in adults is rare and is usually caused by extrinsic compression from a mediastinal tumour. We present the case of a patient with high grade non-Hodgkin's lymphoma who presented with progressive exertional dyspnoea. Compression of the right pulmonary artery was diagnosed by transthoracic echocardiography.
Tsetse flies are the vectors of trypanosomes, the causal agent of trypanosomiasis, a widespread disease of livestock and people in Africa. Control of tsetse may open vast areas of land to livestock-keeping, with the associated benefits of developing mixed crop-livestock production systems. However, as well as possible positive impacts there are also risks:… (More)
Therapeutic hypothermia remains a promising treatment for patients with severe traumatic brain injury (TBI). Multiple animal studies have suggested that hypothermia is neuroprotective after TBI, but clinical trials have been inconclusive. Systemic hypothermia, the method used in almost all major clinical trials, is limited by the time to target temperature,… (More)
Heart failure is increasingly common in western populations and is an inevitable consequence of the improved survival after myocardial infarction, and of an ageing population. Heart failure is usually relentlessly progressive as the maladaptive processes triggered by the physiological changes of the condition lead to further deterioration. However, in… (More)
INTRODUCTION The transesophageal echo probe (TEE) is commonly used before and during atrial fibrillation (AF) ablation under general anesthesia (GA). We sought to determine the potential contribution of the TEE probe to esophageal injury after pulmonary vein isolation (PVI) alone for paroxysmal AF. METHODS AND RESULTS Seventy-six patients undergoing PVI… (More)
BACKGROUND Intravenous omega-3 polyunsaturated fatty acids (ω-3 PUFAs) may prevent atrial fibrillation (AF) inducibility and perpetuation in animal models. We examined the effect of high dose IV ω-3 PUFAs on human atrial electrophysiology. METHODS AND RESULTS We randomised 88 patients with no structural heart disease to receive saline (control group) or… (More)
Forty seven totally implantable venous access systems have been inserted in 45 patients for the management of malignant disease (n = 29), haematological disorders (n = 5), and cystic fibrosis (n = 11). We report our experience with them and discuss the problems we have encountered during the past three years.
Fragmentation and embolization of permanent pacemaker (PPM) leads into the pulmonary circulation is a rare complication of lead extraction procedures. We present two cases of lead tip embolization in patients undergoing lead extraction. The literature pertaining to the incidence and management of lead fragmentation and embolization is discussed.