Timothy Burke

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During anterior-posterior axis specification in the Drosophila embryo, the Hunchback (Hb) protein forms a sharp boundary at the mid-point of the embryo with great positional precision. While Bicoid (Bcd) is a known upstream regulator for hb expression, there is evidence to suggest that Hb effectively filters out "noisy" data received from varied Bcd(More)
Pregabalin has become more widely prescribed and abused in recent years but is still not always included in laboratory analysis. An LC-MS-MS method has been developed and applied to measure pregabalin in 93 postmortem cases, including drug-related deaths, alternative causes of death, and fatalities where pregabalin was likely to have contributed to death.(More)
PURPOSE A growing body of evidence supports an association between coronary heart disease (CHD) and dental diseases, particularly periodontitis (PD). The present study was designed to assess the relationship between childhood dental care and adult CHD in a single community dental clinic. MATERIALS AND METHODS Consecutive patients (n = 223) at a single(More)
would also like to thank those who commented on a post on this subject that I made to the blog Terra Nova (http://terranova.blogs.com); they were instrumental in giving me the opportunity to hone my ability to convey these ideas. At an even earlier stage, a conversation that originated in an online gaming guild first prompted me to attempt to develop these(More)
Patients with Klippel-Feil syndrome (KFS) and associated craniocervical junction abnormalities are at high risk for the development of progressive neurologic deficits. A 60-year-old male patient with Klippel-Feil syndrome was admitted to the emergency room with an 8-year history of a progressive spastic quadraparesis which began with numbness in the right(More)
The recruitment of phagocytic leukocytes to sites of vessel wall injury plays an important role in thrombus dissolution by proteases elaborated on their adhesion. However, leukocyte adhesion to the fibrin clot can be detrimental at the early stages of wound healing when hemostatic plug integrity is critical for preventing blood loss. Adhesion of circulating(More)