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This study investigated the effect of temperature on the oxygen diffusion coefficient (DO2) of hamster retractor muscle from 11 to 37 degrees C. DO2 was measured using a non-steady-state technique, whereas muscle O2 consumption (VO2) was estimated after steady state was reached. DO2 was 0.84 +/- 0.04 x 10(-5) cm2/s at 11 degrees C and rose exponentially to(More)
Blastogenic and cytotoxic responsiveness of peripheral blood leukocytes from the green turtle, Chelonia mydas were examined. Blastogenic responses were low level and showed considerable variation between animals. Blastogenesis in response to phytohemagglutinin and concanavalin A was observed through out all seasons. Responses to pokeweed mitogen and(More)
OBJECTIVE To determine which intraosseous (IO) devices were easy to learn to use, easy to use once the skill was obtained, and appropriate for the Special Operations environment. METHODS Thirty-one Navy SEAL corpsmen, Air Force pararescuemen, Army Special Forces, and Ranger medics, in a prospective, randomly assigned, cross-over study, tested four(More)
A significant number of casualties in previous conflicts died from peripheral vascular wounds. A well-designed tourniquet could possibly have prevented these deaths. The objective of this study was the identification of such a tourniquet. A survey of Special Operations corpsmen established important characteristics necessary in an ideal tourniquet. Because(More)
Hypotensive resuscitation (Hypo) has been considered an alternate resuscitation strategy in clinical settings that prevent the application of standard Advanced Trauma Life Support care. However, validation of this approach when used for prolonged periods of time remains to be demonstrated. The purpose of this study was to evaluate prolonged Hypo as an(More)
Myoglobin (Mb) may facilitate O2 diffusion in muscle tissue, yet models of O2 transport are often simplified by ignoring the role of Mb. A recent analysis of O2 transport in hamster retractor muscle revealed a large discrepancy between the observed O2 diffusion from arterioles and that predicted by a mathematical model that did not include Mb. To establish(More)
Hemorrhagic shock (HS) elicits a global acute inflammatory response, organ dysfunction, and death. We have used mathematical modeling of inflammation and tissue damage/dysfunction to gain insight into this complex response in mice. We sought to increase the fidelity of our mathematical model and to establish a platform for testing predictions of this model.(More)
One of the major limitations in studying the mechanisms of blast-induced traumatic brain injury (bTBI) or screening therapeutics for protection is the lack of suitable laboratory model systems that can closely mimic the complex blast exposure. Although animal models of bTBI that use shock tubes to mimic blast exposure are available, no high throughput shock(More)
BACKGROUND Complex biological processes such as acute inflammation induced by trauma/hemorrhagic shock/ (T/HS) are dynamic and multi-dimensional. We utilized multiplexing cytokine analysis coupled with data-driven modeling to gain a systems perspective into T/HS. METHODOLOGY/PRINCIPAL FINDINGS Mice were subjected to surgical cannulation trauma (ST) ±(More)
BACKGROUND To determine the role of nitric oxide and adenosine triphosphate-sensitive potassium (KATP) vascular channels in vascular decompensation during controlled hemorrhagic shock in swine. METHODS Thirty instrumented, anesthetized adolescent Yorkshire swine were subjected to controlled isobaric hemorrhage to a mean arterial pressure of 40 mmHg for 2(More)