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OBJECTIVE To compare the incidence of hospitalized bacterial infections among children with and children without juvenile idiopathic arthritis (JIA) and to examine the effects of selected medications. METHODS Using national Medicaid data from 2000 through 2005, we identified a cohort of children with JIA and a comparator cohort of children with attention(More)
JASVINDER A. SINGH, DANIEL E. FURST, ASEEM BHARAT, JEFFREY R. CURTIS, ARTHUR F. KAVANAUGH, JOEL M. KREMER, LARRY W. MORELAND, JAMES O’DELL, KEVIN L. WINTHROP, TIMOTHY BEUKELMAN, S. LOUIS BRIDGES JR., W. WINN CHATHAM, HAROLD E. PAULUS, MARIA SUAREZ-ALMAZOR, CLAIRE BOMBARDIER, MAXIME DOUGADOS, DINESH KHANNA, CHARLES M. KING, AMYE L. LEONG, ERIC L. MATTESON,(More)
OBJECTIVE To determine the relative rates of incident malignancy among children with juvenile idiopathic arthritis (JIA) with respect to treatment as compared to children without JIA. METHODS Using national Medicaid data from 2000 through 2005, we identified cohorts of children with JIA and without JIA according to the diagnosis codes used by their(More)
Children with arthritis may endure a lifetime of disfigurement, dysfunction, and pain if acute inflammation progresses to chronic changes in the joint cartilage and underlying bone. Intraarticular steroids have become an integral component of treatment, but at times are difficult to deliver to joints, such as the subtalar joint, that have complex anatomies.(More)
OBJECTIVE To determine the prevalence and features of temporomandibular joint (TMJ) arthritis by magnetic resonance imaging (MRI) among children with juvenile idiopathic arthritis (JIA), and to identify risk factors for TMJ arthritis. METHODS A retrospective chart review was performed on 187 patients with JIA who underwent a TMJ MRI at Children's Hospital(More)
OBJECTIVE Temporomandibular joint (TMJ) arthritis in children with juvenile idiopathic arthritis (JIA) is extremely common but frequently asymptomatic. Magnetic resonance imaging (MRI) with contrast remains the gold standard for identifying TMJ arthritis in JIA. A reliable scoring system with published MRI examples of typical acute and chronic TMJ arthritis(More)
CONTEXT Although tumor necrosis factor (TNF)-α antagonists are increasingly used in place of nonbiologic comparator medications, their safety profile remains incomplete. OBJECTIVES To determine whether initiation of TNF-α antagonists compared with nonbiologic comparators is associated with an increased risk of serious infections requiring hospitalization.(More)
INTRODUCTION Potential hepatotoxicity associated with disease-modifying antirheumatic drugs (DMARDs) requires laboratory monitoring. In patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA), the incidence of elevated alanine aminotransferase/aspartate aminotransferase (ALT/AST) enzymes associated with methotrexate (MTX), leflunomide (LEF) and(More)
OBJECTIVE To compare incidence rates of selected opportunistic infections among children with and children without juvenile idiopathic arthritis (JIA). METHODS Using U.S. national Medicaid administrative claims data from 2000 through 2005, we identified a cohort of children with JIA based on physician diagnosis codes and dispensed medications. We also(More)