Timothé Escudé

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The neural cell adhesion molecule NCAM and its association with the polysialic acid (PSA) are believed to contribute to brain structural plasticity that underlies memory formation. Indeed, the attachment of long chains of PSA to the glycoprotein NCAM down-regulates its adhesive properties by altering cell–cell interactions. In the brain, the biosynthesis of(More)
embryonic day 18.5 (E18.5) Notch inactivation leads to a reduction in EGL thickness compared to Shh activated mice. As mice carrying homozygous Notch inactivation die after birth we are further investigating change of tumourigenicity by injecting cells harvested from E18.5 cerebellum into SCID mice. In the developing cerebral cortex different types of(More)
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