Timo Vuorela

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This paper describes a design and implementation of a portable physiological signal recorder. The device is designed for measuring electrocardiography, bioimpedance, and user's activity. The bioimpedance measures the dynamic changes in the impedance, and its main application is monitoring user's respiration. Activity is measured with three-axis acceleration(More)
Spheroidal high-density lipoprotein (HDL) particles circulating in the blood are formed through an enzymatic process activated by apoA-I, leading to the esterification of cholesterol, which creates a hydrophobic core of cholesteryl ester molecules in the middle of the discoidal phospholipid bilayer. In this study, we investigated the conformation of apoA-I(More)
We study the structure and dynamics of spherical high density lipoprotein (HDL) particles through coarse-grained multi-microsecond molecular dynamics simulations. We simulate both a lipid droplet without the apolipoprotein A-I (apoA-I) and the full HDL particle including two apoA-I molecules surrounding the lipid compartment. The present models are the(More)
The simulated lipid droplet contained 630 1-palmitoyl-2-oleoyl-3-phosphatidylcholine (POPC), 80 1-palmitoyl-3-phosphatidylcholine (denoted as lysoPC in the main article), 600 cholesterol (CHOL), 1600 cholesteryl oleate (CO), and 180 trioleate (TO) molecules. This molecular composition is similar to the average physiological composition seen in experiments(More)
In smart homes, unobtrusive monitoring of user position and activity are important but challenging tasks. With the current state of technology, this task is especially hard to carry out in private areas where video surveillance is considered undesirable or even offensive. Even though some alternative methods for passive and unobtrusive monitoring of people(More)
Cholesteryl ester transfer protein (CETP) transports cholesteryl esters, triglycerides, and phospholipids between different lipoprotein fractions in blood plasma. The inhibition of CETP has been shown to be a sound strategy to prevent and treat the development of coronary heart disease. We employed molecular dynamics simulations to unravel the mechanisms(More)
Elderly people with no or limited skills of using computers are in risk of social isolation as social life moves to the Internet. This paper describes the design process and implementation of a user interface and device for the elderly for a social networking application. The idea is that people with no previous experience on using computers are able to use(More)
This paper presents an implementation of two portable measurement device prototypes. Both prototypes are targeted for measuring ECG and bioimpedance signals. The first prototype is a wireless type, which sends data in real-time to a PC. The second prototype is a logging device, which stores data to a memory card. After a measurement session data from memory(More)