Timo Schirmer

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The reliability of a single-voxel, localized proton magnetic resonance spectroscopy protocol suitable for clinical studies was investigated by means of in vitro, single-subject in vivo and multi-subject in vivo examinations of healthy adults aged from 19 to 67 years. The study was performed at 1.5 T using a standard quadrature head coil and a single voxel(More)
Gradient-echo (GRE) and spin-echo (SE) EPI BOLD sequences were used to quantitate the effect of visual stimulation. Both sequences showed a positive BOLD response during stimulation and a negative BOLD response in the interstimulation intervals. The relaxation rate changes during stimulation were larger for the GRE sequence than for the SE sequence, whereas(More)
OBJECTIVE The purpose of our study was to show how, despite pathognomonic signs of cerebral involvement in chronic progressive external ophthalmoplegia (CPEO), mitochondrial respiratory chain insufficiency is associated with increased lactate and reduced N-acetylaspartate. CPEO and mitochondrial myopathy are caused by mitochondrial DNA mutations leading to(More)
OBJECTIVE Subcortical white matter hyperintensities (WMH) and small cystic lesions are the radiologic hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary angiopathy causing stroke in young adults. To further characterize the cerebral pathology in vivo we analyzed metabolite(More)
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