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OBJECTIVE To determine parameters of perfusion, distribution coefficient, and glucose metabolism as part of the tumour-specific micromilieu of breast cancer and compare them with corresponding values in normal breast tissue. METHODS H2(15)O PET and 18F-FDG PET were performed on 10 patients with advanced invasive ductal carcinomas of the breast. Perfusion,(More)
This paper systematically evaluates a pharmacokinetic compartmental model for identifying tumor hypoxia using dynamic positron emission tomography (PET) imaging with 18F-fluoromisonidazole (FMISO). A generic irreversible one-plasma two-tissue compartmental model was used. A dynamic PET image dataset was simulated with three tumor regions-normoxic, hypoxic(More)
BACKGROUND Targeted radionuclide therapy is a rapidly growing modality. A few commercial treatment planning systems are entering the market. However, some in-house systems are currently developed for a more flexible and customized dosimetry calculation at voxel-level. For this purpose, we developed a novel software, VoxelMed, and performed a comparison with(More)
We examine diffractive proton-proton scattering p p → p X and photoand electroproduction of ρ0 mesons γ(∗) p → ρ0 X, where X denotes a proton or a final state, into which the proton can go by diffractive dissociation. Using a functional integral approach we derive the scattering amplitudes, which are governed by the expectation values of light-like(More)
We evaluate a fully data-driven method for the combined recovery and motion blur correction of small solitary pulmonary nodules (SPNs) in F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). The SPN was segmented in the low-dose CT using a variable Hounsfield threshold and morphological constraints. The combined effect(More)
We present an automated scheme to correct PET max-uptake-values of small to medium-sized pulmonary nodules for motion blur and partial volume averaging. Both effects cause significant underestimation of PET max-uptake-values, particularly in nodules below 25 mm diameter, but nodules up to 75 mm might be affected. This compromises the power of PET for the(More)
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