Tim Youngs

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1. A number of compounds structurally related to GABA were tested as inhibitors of baclofen-sensitive GABAB receptor binding to membranes from mouse brain. 2. In addition to two known inhibitors--baclofen and 5-aminovaleric acid--two analogues were shown to possess inhibitory activity. These compounds were 4-aminobutyryl-DL-alanine hydrobromide (IC50 = 3(More)
The Congo as topos of dystopic transgression in fin-de-siècle literature In this essay, I compare the representation of the Congo as a topos of dystopic transgression in Conrad’s Heart of Darkness (1902), and in a lesser-known novel entitled Tropenwee (Tropical agony) by the Dutch author Henri van Booven, published in 1904. The idea of the Congo as a locus(More)
The nucleotide ATP was shown to be a reversible inhibitor of partially purified gamma-aminobutyrate aminotransferase isolated from mouse brain. This inhibition was of the competitive type with respect to the substrate, gamma-aminobutyric acid (Ki = 3.7 +/- 0.6 mM), but was noncompetitive with respect to both the second substrate alpha-ketoglutarate and the(More)
To examine the idea that glutamate decarboxylase from E. coli can be a convenient source for the study of the effects of compounds on GABA synthesis in the nervous system, a series of substrate analogues and divalent cations were tested as potential inhibitors of the bacterial enzyme. Those analogues exhibiting inhibitor activity did so in a competitive(More)
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