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Aspirin is a unique nonsteroidal anti-inflammatory drug; at high doses (aspirin(high), 1g), it is anti-inflammatory stemming from the inhibition of cyclooxygenase and proinflammatory signaling pathways including NF-kappaB, but is cardioprotective at lower doses (aspirin(low), 75 mg). The latter arises from the inhibition of thromboxane (Tx) B(2), a(More)
BACKGROUND Endothelin (ET)-l is a bronchoconstrictor peptide produced in the airways. It has been implicated in the pathogenesis of asthma and virally mediated airway inflammation and may play a role in exacerbations of chronic obstructive pulmonary disease (COPD). METHODS Seventy one patients with COPD were followed prospectively and sampled for plasma(More)
acquiring, integrating, analyzing and applying digital information to support sustainable forests.” The closely related term, “Digital Forest,” is defined as “a digital representation of forestry information.” These concepts and definitions were developed at “The 1 International Workshop on Digital Forestry,” June 13–19, 2004 in Beijing, China, which was(More)
Coronary artery disease is the leading cause of mortality in the West with over 1.2 million angioplasties performed annually. Despite the introduction of stents, restenosis occurs in 30-40% of vessels, which until recently has only been treated effectively by coronary artery bypass surgery. Coronary artery brachytherapy appears to provide an alternative,(More)
Non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat the condition of rheumatoid arthritis, where levels of prostaglandin E2 (PGE2) and granulocyte macrophage-colony stimulating factor (GM-CSF) are elevated in the synovial fluid. NO-NSAIDs are a new class of cyclooxygenase (COX)-inhibitors developed by coupling a nitric oxide (NO)-donating(More)
Paul Oestreicher is head of the US Healthcare Practice for Hill & Knowlton, 909 Third Avenue, New York, NY 10022 and Tim Warner leads its Washington, DC-based healthcare team, 607 Fourteenth Street, NW, Suite 300, Washington, DC 20005. e-mail: paul.oestreicher@hillandknowlton.com or tim.warner@hillandknowlton.com Industry observers assert that the biotech(More)
Paul Oestreicher is head of the US Healthcare Practice for Hill & Knowlton, 909 Third Avenue, New York, NY 10022 and Tim Warner leads its Washington, DC-based healthcare team, 607 Fourteenth Street, NW, Suite 300, Washington, DC 20005. e-mail: paul.oestreicher@hillandknowlton.com or tim.warner@hillandknowlton.com Industry observers assert that the biotech(More)
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