Tim Ting-Chung Yen

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Fluoxetine selectively inhibits serotonin uptake in vitro and in vivo and thus enhances serotonergic function, leading to a decrease in food intake beginning with the first dose and a decrease in body weight or in weight gain after multiple doses of fluoxetine. Fluoxetine and other drugs that increase serotonergic function decrease food intake with(More)
Hepatitis B virus (HBV) is a driver of hepatocellular carcinoma, and two viral products, X and large surface antigen (LHBS), are viral oncoproteins. During chronic viral infection, immune-escape mutants on the preS2 region of LHBS (preS2-LHBS) are gain-of-function mutations that are linked to preneoplastic ground glass hepatocytes (GGHs) and early disease(More)
Satietin a recently discovered potent endogenous anorectic agent was claimed to be a highly selective anorectic substance, devoid of any effect on other behavioral system. In the copulator male rats, in contrast to amphetamine, fenfluramine and fluoxetine it failed to influence the mating activity. This finding further supports the view that satietin has(More)
The effects of single doses of (-)deprenyl, in comparison to J-508, U-1424, pargyline and clorgyline, on the sexual performance of male rats were tested. (-)Deprenyl (0.25 and 1 mg/kg, respectively) exerted a true, long-lasting aphrodisiac effect, on sexually sluggish male rats, whereas clorgyline, U-1424 and J-508 failed to act similarly. Pargyline(More)
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